183373-91-3

Upstream product

• 719-59-5 5-chloro-2-aminobenzophenone 
• 120-92-3 cyclopentanone 
• 536-74-3 phenylacetylene 
• 16664-48-5 6-bromo-1-phenyl-1-hexyne 
• 856120-87-1 (6-azidohex-1-yn-1-yl)benzene 
• 144930-52-9 (4-chlorophenyl)(phenyl)iodonium triflate 
• 2835-77-0 (2-aminophenyl)(phenyl)methanone 

Relevant academic research and scientific papers

Synthesis and structure of 6-chloro-2,3-trimethylene-4-phenylquinoline

An X-ray structural investigation of 6-chloro-2,3-trimethylene-4-phenylquinoline obtained by the reaction of 2-amino-5-chlorobenzophenone with cyclopentanone was carried out. At 20°C, a = 23.750, b = 9.242, c = 14.018 A?, β= 112.68°, space group C2/c, Z =

Environmentally Friendly Nafion-Mediated Friedl?nder Quinoline Synthesis under Microwave Irradiation: Application to One-Pot Synthesis of Substituted Quinolinyl Chalcones

An efficient and eco-friendly synthetic route for Friedl?nder quinoline synthesis of polysubstituted quinolines is described. This green chemical method starts from various 2-aminobenzophenones and mono- or dicarbonyl synthons and uses reusable Nafion NR50 material as a solid catalyst in ethanol under microwave irradiation. The protocol has a high generality of functional groups and provides the desired quinolines in good to excellent yields. Some structures were confirmed by single-crystal X-ray diffraction analysis.

Synthesis of neocryptolepines and carbocycle-fused quinolines and evaluation of their anticancer and antiplasmodial activities

This study reported the discovery of novel compounds containing five-membered ring fused quinoline core structures as anticancer and antimalarial agents. Two libraries containing these core structures, neocryptolepines and carbocycle-fused quinolines, were prepared and evaluated. Compound 3h was found to be much more potent than other analogs against cancer cell lines with high selectivity. Meanwhile, carbocycle-fused quinolines 5h and 5s showed moderate anticancer properties but much less cytotoxicity to normal cell than doxorubicin. In addition, compound 3h also showed much lower cytotoxic against human normal kidney cell line compared to doxorubicin standard. However, only compounds 3s and 3p provided acceptable results for antimalarial activities.

Domino N2-Extrusion-Cyclization of Alkynylarylketone Derivatives for the Synthesis of Indoloquinolines and Carbocycle-Fused Quinolines

New synthetic approaches for the synthesis of indoloquinolines and carbocycle-fused quinolines have been developed employing alkynylketone substrates. These synthetic transformations involved the application of N2-extrusion of azido complexes as a key step to generate carbodiimidium ion and nitrilium ion in situ, which further cyclized intramolecularly with alkyne via a domino process to provide indoloquinolines and carbocycle-fused quinolines, respectively, in moderate to good yields.

Imidazole-functionalized magnetic Fe3O4 nanoparticles: an efficient, green, recyclable catalyst for one-pot Friedl?nder quinoline synthesis

An efficient and cost-effective procedure for preparation of Fe3O4 nanoparticles and supported Br?nsted acidic ionic liquid 1-methyl-3-(3-trimethoxysilylpropyl)imidazolium hydrogen sulfate (Fe3O4-IL-HSO4/s

Convenient and efficient method for the synthesis of substituted quinolines via one-pot heteroannulation reaction of o-amino arylketones with α-methylene ketones under solvent-free conditions

A facile and practical approach to the synthesis of a wide range of functionalized quinolines was developed via a tandem heteroannulation reaction of o-aminoarylketones with diverse α-methylene ketones in high yields by using tetrabutylammonium peroxydisu

A green biosynthesis of NiO nanoparticles using aqueous extract of Tamarix serotina and their characterization and application

Nickel oxide nanoparticles were prepared using nickel nitrate as precursor with extract of Tamarix serotina flowers and were characterized using powder X-ray diffraction, infrared and UV spectroscopies, transmission electron microscopy, vibrating sample m

3-Methyl-1-sulfoimidazolium ionic liquids as recyclable medium for efficient synthesis of quinoline derivatives by Friedl?nder annulation

Two acidic ionic liquids, 3-methyl-1-sulfoimidazolium trichloroacetate ([Msim][OOCCCl3]) and 3-methyl-1-sulfoimidazolium chloride ([Msim]Cl) were efficiently utilized as recyclable acidic homogeneous medium for the Friedl?nder synthesis of quin

Nickel nanoparticles: A highly efficient and retrievable catalyst for the solventless Friedlander annulation of quinolines and their in silico molecular docking studies as histone deacetylase inhibitors

The present work explores a highly efficient, environmental friendly, green, solvent-free protocol for the preparation of polysubstituted quinolines via Friedlander annulation using nickel nanoparticles (80-100 nm) biofabricated from Aegle Marmelos Correa

Fe3O4@SiO2-imid-PMAn magnetic porous nanosphere as reusable catalyst for synthesis of polysubstituted quinolines under solvent-free conditions

In this research, a facile one-pot synthesis of poly-substituted quinoline derivatives has been demonstrated by using 2-aminobenzophenones and ethylacetoacetate or ketones in the presence of Fe3O4@SiO2-imid-PMAn