18338-90-4

Usage

Class of organic compounds

Phenyl-3-furancarboxylic acids and derivatives

Common uses

Flavoring agent, pharmaceutical synthesis

Odor

Sweet, fruity

Properties

Antimicrobial, antioxidant

Applications

Personal care, cosmetics

Safety precautions

Harmful if swallowed or inhaled, may cause skin and eye irritation

InChI:InChI=1/C10H7ClO2/c11-8-3-1-7(2-4-8)9-5-6-10(12)13-9/h1-5H,6H2

Upstream product

• 3984-34-7 4-(4-chlorophenyl)-4-oxobutanoic acid 
• 851484-24-7 2-(4-chlorophenyl)-5-oxotetrahydrofuran-3-carboxylic acid 
• 637-87-6 1-Chloro-4-iodobenzene 
• 142335-92-0 5-(4-chlorophenyl)-2-(1,1-dimethylethoxy)furan 
• 75-36-5 acetyl chloride 

Downstream Products

• 60721-33-7 1-(4-chlorophenyl)-4-phenylbutane-1,4-dione 
• 1079-73-8 6-(4-chlorophenyl)-4,5-dihydro-3(2H)-pyridazinone 
• 84023-91-6 (E)-3-(benzo[d][1,3]dioxol-5-ylmethylene)-5-(4-chlorophenyl)-furan-2(3H)-one 

Relevant academic research and scientific papers

A Piperine-Based Scaffold as a Novel Starting Point to Develop Inhibitors against the Potent Molecular Target OfChtI

The insect chitinase OfChtI from the agricultural pest Ostrinia furnacalis (Asian corn borer) is a promising target for green insecticide design. OfChtI is a critical chitinolytic enzyme for the cuticular chitin degradation at the stage of molting. In thi

Convenient synthesis of α,β-unsaturated γ-butyrolactones and γ-butyrolactams via decarboxylative iodination of paraconic acids and β-carboxyl-γ-butyrolactams using 1,3-diiodo-5,5-dimethylhydantoin

A convenient synthetic approach to α,β-unsaturated γ-butyrolactones and α,β-unsaturated γ-butyrolactams is developed. The reaction proceeds via decarboxylative iodination of paraconic acids and β-carboxyl-γ-butyrolactams, employing 1,3-diiodo-5,5-dimethylhydantoin (DIH) under irradiation, followed by dehydroiodination of β-iodo-γ-butyrolactones and γ-butyrolactams providing good yields of α,β-unsaturated γ-butyrolactones and γ-butyrolactams, which are synthetically useful building blocks in organic synthesis.

2-Trialkylstannyl-5-tert-butoxyfurans: Convenient 5-substituted-2(3H)-furanone synthons

A versatile and mild route on 5-substituted-2(3H)-furanones (butenolides) from the palladium catalyzed coupling of aryl halides and 2-trialkylsannyl-5-tert-butoxyfurans is described.

Some Observations Concerning the Lactonization of 3-Aroylpropionic Acids

The ease of lactonization og the γ-keto acids ArCOCH2CH2COOH is shown to depend on the nature of the aryl group: the presence of electron-releasing substituents on the aryl group results in a more rapid reaction as compared to the presence of electron-wit

Reactions of some Δβ,γ-Butenolides Having no Exocyclic Double bonds

Ring-opening of γ-aryl-Δβ,γ-butenolides (I) takes place in a different manner compared to those having an exocyclic double bond at the α-position.I react with hydrazine hydrate in cold or boiling ethanol to give 6-aryl-4,5-dihydropyridazine-3(2