183437-94-7

Basic information

• Product Name: Pyrimidine, 5-bromo-2-(4-fluorophenyl)- (9CI)
• Synonyms: Pyrimidine, 5-bromo-2-(4-fluorophenyl)- (9CI);Pyrimidine, 5-bromo-2-(4-fluorophenyl)-
• CAS NO: 183437-94-7
• Molecular Formula: C₁₀H₆BrFN₂
• Molecular Weight: 253.0704432
• Product Categories: QUINAZOLINE;PYRIMIDINE
• Mol File: 183437-94-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Pyrimidine, 5-bromo-2-(4-fluorophenyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrimidine, 5-bromo-2-(4-fluorophenyl)- (9CI)(183437-94-7)
• EPA Substance Registry System: Pyrimidine, 5-bromo-2-(4-fluorophenyl)- (9CI)(183437-94-7)

Safety Data

• Hazardous Substances Data: 183437-94-7(Hazardous Substances Data)

Upstream product

• 1765-93-1 4-fluoroboronic acid 
• 183438-24-6 5-bromo-2-iodopyrimidine 
• 352-13-6 4-flourophenylmagnesium bromide 

Downstream Products

• 1187370-34-8 5-(4-tert-butyl-phenyl)-2-(4-fluoro-phenyl)-pyrimidine 
• 183438-29-1 2-(4'-Fluorophenyl)-5-pent-1-ynylpyrimidine 
• 95495-03-7 2-p-fluorophenyl-5-n-pentylpyrimidine 

Relevant articles and documents

C?I-Selective Cross-Coupling Enabled by a Cationic Palladium Trimer

While there is a growing interest in harnessing synergistic effects of more than one metal in catalysis, relatively little is known beyond bimetallic systems. This report describes the straightforward access to an air-stable Pd trimer and presents unambiguous reactivity data of its privileged capability to differentiate C?I over C?Br bonds in C?C bond formations (arylation and alkylation) of polyhalogenated arenes, which typical Pd0 and PdI-PdI catalysts fail to deliver. Experimental and computational reactivity data, including the first location of a transition state for bond activation by the trimer, are presented, supporting direct trimer reactivity to be feasible.

Synthesis and characterization of cyclometalated iridium(III) complexes containing pyrimidine-based ligands

New pyrimidine derivatives (pyr) have been synthesized using palladium-catalyzed Suzuki coupling reaction. These compounds can undergo cyclometalation with iridium trichloride to form bis-cyclometalated iridium complexes, (pyr)2Ir(acac) (acac =

5-Bromo-2-iodopyrimidine: A novel, useful intermediate in selective palladium-catalysed cross-coupling reactions for efficient convergent syntheses

A simple synthesis of the novel 5-bromo-2-iodopyrimidine is described and examples are provided of the use of the compound in selective palladium-catalysed cross-coupling reactions with a wide range of arylboronic acids and alkynylzincs to give the efficient syntheses of many substituted pyrimidine compounds.