18346-06-0

Upstream product

• 120-73-0 purine 
• 100-51-6 benzyl alcohol 
• 3010-05-7 benzylaminoacetonitrile 
• 3473-63-0 formamidine acetic acid 
• 87-42-3 6-chloropurine 
• 150721-88-3 7-benzyl-6-iodo-7H-purine 
• 100-46-9 benzylamine 
• 122-51-0 orthoformic acid triethyl ester 
• 1928-77-4 7-benzyl-6-chloro-7H-purine 
• 100-44-7 benzyl chloride 
• 1461-25-2 tetra-n-butyltin(IV) 
• 17049-50-2 n-decyl magnesium bromide 
• 109-72-8 n-butyllithium 

Relevant academic research and scientific papers

Rapid construction of imidazopyridines from ortho-haloaminopyridines

A practical strategy for the preparation of imidazopyridine derivatives from ortho-haloaminopyridines utilizing a two-step C-N coupling/cyclization reaction sequence has been developed. This procedure provides rapid and efficient access to many medicinally interesting imidazopyridine compounds and related imidazopyrazine/purine heterocycles.

Preparation and crystal structures of purine 2,2′-, 6,6′-, and 8,8′-dimers

Treatment of 9- or 7-substituted 6-, 2-, or 8-iodopurine derivatives with copper(I) thiophene-2-carboxylate or copper(I) 3-methylsalicylate in N,N-dimethylformamide affords the corresponding 6,6′-, 2,2′-, and 8,8′-purine dimers in high yield. Cross-dimeri

Synthesis and biological testing of purine derivatives as potential ATP-competitive kinase inhibitors

On the basis of ATP adenine, a series of adenine and purine derivatives was prepared and tested for their ability to inhibit a spectrum of disease-related kinases. There has been scant research investigating the potential of cosubstrate derived kinase inhibitors for other kinases than CDKs. Our inhibitor design combined the purine system from the original cosubstrate ATP and phenyl moieties in order to explore possible interactions with the different regions of the ATP binding site in several disease-related protein kinases. There have been a number of hits for the assayed substances, which led us to conclude that the spectrum of compounds may prove to be a valuable tool kit for the evaluation of bonding and selectivity patterns for a wide variety of kinases.

6-Halopurines in palladium-catalyzed coupling with organotin and organozinc reagents

N-9 and N-7 benzylated 6-halopurines readily participate in palladium catalyzed cross coupling reactions with organotin and organozinc derivatives. In most instances the 6-chloropurines can be used. Organostannanes are excellent reagents for the introduction of alkenyl and aryl substituents, but organozinc compounds are the reagents of choice for the introduction of alkyl groups.

Mitsunobu reactions for the synthesis of carbocyclic analogues of nucleosides: Examintion of the regioselectivity

In order to provide a general synthetic method for carbocyclic nucleosides, regioselectivities in Mitsunobu reaction of purine, pyrimidin-2-one and their substituted derivatives with a variety of alcohols with a variety of alcohols were examined and found to depend upon both substituents of the bases and kind of the alcohols.