183546-38-5Relevant articles and documents
Synthesis and biological evaluation of 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acids against Vaccinia virus
Azevedo, Alexandre R.,Ferreira, Vitor F.,De Mello, Heloisa,Leao-Ferreira, Luiz R.,Jabor, Alfredo V.,Frugulhetti, Izabel C. P. P.,Pereira, Helena S.,Moussatche, Nissin,Bernardino, Alice M. Rolim
, p. 427 - 432 (2002)
Several new 3-phenyl and 3-alkyl-1H-pyrazolo[3,4-b]pyridine derivatives (3a-e) were prepared and evaluated against Vaccinia virus on BSC-40 cells. The derivatives 3a, 3b and 3d showed an inhibitory activity above 90% at 30 μM, 40 μM and 50 μM concentrations.
SAR of a series of anti-HSV-1 acridone derivatives, and a rational acridone-based design of a new anti-HSV-1 3H-benzo[b]pyrazolo[3,4-h]-1,6-naphthyridine series
Bernardino, Alice M.R.,Castro, Helena C.,Frugulhetti, Izabel C.P.P.,Loureiro, Natalia I.V.,Azevedo, Alexandre R.,Pinheiro, Luiz C.S.,Souza, Thiago M.L.,Giongo, Viveca,Passamani, Fabiana,Magalhaes, Uiaran O.,Albuquerque, Magaly G.,Cabral, Lucio M.,Rodrigues, Carlos R.
, p. 313 - 321 (2008/04/05)
Herpes Simplex Virus (HSV) infections are among the most common human diseases. In this work, we assess the structural features and electronic properties of a series of ten 1-hydroxyacridone derivatives (1a-j) recently described as a new class of non-nucl
New tetracyclic heteroaromatic ring system 3H-benzo[b]pyrazolo[3, 4-h]-1, 6-naphthyridines
De Azevedo, Alexandre Reis,Frugulhetti, Izabel C.P.P.,Khan, Misbahul Ain,Khakwani, Samia,Bernardino, Alice M. Rolim
, p. 47 - 54 (2007/10/03)
Various derivatives of the tetracyclic ring system 3H-Benzo[b]pyrazolo[3,4-h]-1,6-naphthyridine were prepared from 4-anilino-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acids by intramolecular cyclization employing phophoryl chloride. 1H NMR spectra of the various derivatives were recorder.
