18355-75-4

Usage

Uses

Used in Pharmaceutical Industry:
2,3-Difluorobenzoic acid is used as an intermediate in the synthesis of various pharmaceuticals, leveraging its unique chemical properties to contribute to the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
2,3-DIFLUOROBENZOIC ACID also serves as an intermediate in the production of agrochemicals, where its fluorinated structure can enhance the effectiveness of pesticides and other agricultural chemicals.
Used in Organic Synthesis:
2,3-Difluorobenzoic acid is utilized as a building block in organic synthesis, particularly for the creation of other fluorinated aromatic compounds, which are valuable in various chemical and material applications.

InChI:InChI=1/C7H5F2NO/c8-5-3-1-2-4(6(5)9)7(10)11/h1-3H,(H2,10,11)

Upstream product

• 21524-39-0 2,3-difluorobenzonitrile 
• 55-21-0 benzamide 
• 2646-91-5 2,3-difluorobenzaldehyde 

Downstream Products

• 1307314-05-1 3-fluoro-2-(4-formyl-3-methylpyrazol-1-yl)benzamide 
• 1307313-25-2 3-fluoro-2-[4-[(2-fluorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)methyl]-3-methylpyrazol-1-yl]benzamide (L)-tartrate 

Relevant academic research and scientific papers

Ti-superoxide catalyzed oxidative amidation of aldehydes with saccharin as nitrogen source: Synthesis of primary amides

A new heterogeneous catalytic system (Ti-superoxide/saccharin/TBHP) has been developed that efficiently catalyzes oxidative amidation of aldehydes to produce various primary amides. The protocol employs saccharin as amine source and was found to tolerate a wide range of substrates with different functional groups. Moderate to excellent yields, catalyst reusability and operational simplicity are the main highlights. A possible mechanism and the role of the catalyst in oxidative amidation have also been discussed.

Electrochemical fluorination of benzamide and acetanilide in anhydrous HF and in acetonitrile

Electrochemical fluorination of benzamide in anhydrous hydrogen fluoride does not involve the amide group but occurs exclusively at the aromatic ring, yielding isomeric fluoro- and difluorobenzamides and 3,3,6,6-tetrafluoro-1,4- cyclohexadienecarboxamide.

Histamine analogues. 33rd communication: 2-phenylhistamines with high histamine H1-agonistic activity

2-Phenylhistamines with various substituents at the phenyl ring were synthesized and the influence of substitution in ortho, meta or para position on histamine H1-agonistic activity was investigated.Compounds with high activity occured in the meta phenyl series.Increased activity in the guinea-pig ileum assay was achieved by monosubstitution with halogen on the phenyl ring. 2-ethanamine (12) is the most potent highly selective H1-agonist known so far, showing 87percent relative potency compared with histamine and full efficacy at theH1-receptor.Relative activities of the 3-chloro analogue (11) and the 3-methyl analogue (13) are 81percent and 29percent, respectively.Histamine H2-activity could not be detected. 2-Phenylhistamines are available via reaction of the corresponding benzimidates with 2-oxo-4-phthalimido-1-butyl acetate (6) in liquid ammonia.