183551-11-3

Basic information

• Product Name: 3-Pyridinecarboxamide, N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-2-chloro-N-(2-hydroxyethyl)-5- methyl-4-phenyl-
• CAS NO: 183551-11-3
• Molecular Formula: C24H19ClF6N2O2
• Molecular Weight: 516.87
• Mol File: 183551-11-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-Pyridinecarboxamide, N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-2-chloro-N-(2-hydroxyethyl)-5- methyl-4-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinecarboxamide, N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-2-chloro-N-(2-hydroxyethyl)-5- methyl-4-phenyl-(183551-11-3)
• EPA Substance Registry System: 3-Pyridinecarboxamide, N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-2-chloro-N-(2-hydroxyethyl)-5- methyl-4-phenyl-(183551-11-3)

Safety Data

• Hazardous Substances Data: 183551-11-3(Hazardous Substances Data)

Upstream product

• 183551-51-1 3,5-bis(trifluoromethyl)benzyl methanesulfonate 
• 713518-42-4 ethyl 2-cyano-5-(dimethylamino)-4-methyl-3-phenylpenta-2,4-dienoate 
• 713518-45-7 ethyl 2-chloro-5-methyl-4-phenylnicotinate 
• 183551-52-2 2-chloro-5-methyl-4-phenylnicotinic acid 
• 93-55-0 1-phenyl-propan-1-one 
• 32707-89-4 3,5-bis(trifluoromethyl)benzenemethanol 
• 13434-46-3 ethyl 2-cyano-3-phenylpent-2-enoate 
• 156241-24-6 2-[[3,5-bis(trifluoromethyl)benzyl]amino]-1-ethanol 

Relevant articles and documents

Amide-based atropisomers in tachykinin NK1-receptor antagonists: Synthesis and antagonistic activity of axially chiral N-benzylcarboxamide derivatives of 2,3,4,5-tetrahydro-6H-pyrido[2,3-b][1,5]oxazocin-6-one

A series of novel N-benzylcarboxamide derivatives of bicyclic compounds, 3,4-dihydropyrido[3,2-f][1,4]oxazepin-5(2H)-one and 2,3,4,5-tetrahydro-6H- pyrido[2,3-b][1,5]oxazocin-6-one, were synthesized by cyclization of N-benzyl-2-chloro-N-(2-hydroxyethyl)-

DRUGS

The present invention relates to a medicine which comprises a compound (I) of the formula:[wherein the ring M is a heterocylic ring having -N=Ca and Rb are bound to each other to form the ring A, or they are the same or different each representing a hydrogen atom or a substituent on the ring M;the rings A and B each is an optionally substituted homocycle or heterocycle, and at least one of them is an optionally substituted heterocycle;the ring C is an optionally substituted homocycle or heterocycle;the ring Z is an optionally substituted nitrogen-containing heterocycle; andn is an integer of 1 to 6] or a salt thereof in combination with a drug having an emetic action. The compounds (I) or their salts are useful as anti-emetic drugs. Particularly, vomiting caused by drugs having an emetic action can be inhibited by these compounds rapidly and safely at a low dose.