1836-77-7

Usage

Synthesis

4-Cyanotetrahydropyran can be obtained by chlorination of phenol with chlorine gas to obtain 2,4,6-trichlorophenol, which is then condensed with p-nitrochlorobenzene.

Uses

Herbicide.

Safety Profile

Low toxicity by ingestion and skincontact. Mutation data reported. Used as an herbicide.When heated to decomposition it emits very toxic fumesof NOx and Clí.

Metabolic pathway

Degradation of chlornitrofen by microorganisms isolated from soils gives rise to the reduction of the nitro group of chlornitrofen to the amino analog, and the successive N-acetylation or N-methylation and the cleavage of the ether linkage are dominant metabolic pathways. The metabolic pathways, however, differ depending on microorganisms and the media. The replacement of the amino group by hydroxyl group, the reduction and successive formylation of p-nitrophenol, and the cleavage of the phenyl ring ultimately to produce CO2 are also observed.

InChI:InChI=1/C48H30Cl6N2O5/c49-39-19-7-1-13-29(39)33-25-47(55(57)58,37-17-5-11-23-43(37)53)26-34(30-14-2-8-20-40(30)50)45(33)61-46-35(31-15-3-9-21-41(31)51)27-48(56(59)60,38-18-6-12-24-44(38)54)28-36(46)32-16-4-10-22-42(32)52/h1-28,45-46H

Upstream product

• 350-46-9 4-Fluoronitrobenzene 
• 88-06-2 2,4,6-Trichlorophenol 
• 100-00-5 4-chlorobenzonitrile 

Downstream Products

• 99226-42-3 N-hydroxy-4-(2,4,6-trichlorophenoxy)aniline 
• 98911-09-2 2,4,6-Trichloro-4'-hydroxyacetylaminobiphenyl ether 
• 99226-48-9 sodium 1-deoxy-1--β-D-glucopyranuronate 
• 98911-13-8 3,4,6-tri-O-acetyl-1,2-O-<1-ethylidene>-α-D-glucopyranose 
• 98911-17-2 N-acetyl-4-(2,4,6-trichlorophenoxy)anilino 2,3,4,6-tetra-O-acetyl-β-D-glucopyranoside 
• 98911-25-2 N-acetyl-4-(2,4,6-trichlorophenoxy)anilino β-D-glucopyranoside 
• 99237-44-2 1-deoxy-1--β-D-glucopyranose 
• 99226-52-5 1-deoxy-1--D-glucofuranurono-6,3-lactone 
• 98911-21-8 (2R,3S,4S,5R,6S)-2-Hydroxymethyl-6-{N-[4-(2,4,6-trichloro-phenoxy)-phenyl]aminooxy}-tetrahydro-pyran-3,4,5-triol 
• 71861-68-2 2,4,6-Trichloro-4'-acetylaminobiphenyl ether 

Relevant academic research and scientific papers

CsF/clinoptilolite: An efficient solid base in SNAr and copper-catalyzed Ullmann reactions

CsF/clinoptilolite was found to be an efficient solid base catalyst for both SNAr and Ullmann ether reactions. A general and efficient one-step procedure was developed for the synthesis of biaryl ethers via direct coupling of electron-deficient aryl halides to phenols using CsF/clinoptilolite. The protocol was also applied to electron-rich aryl halides by addition of a catalytic amount of copper oxide nanoparticles. Both SNAr and Ullmann reactions were rapid and provided good to excellent yields.

Potassium fluoride supported on natural nanoporous zeolite: A new solid base for the synthesis of diaryl ethers

An efficient and inexpensive synthesis of diaryl ethers has been developed. The process involves the nucleophilic aromatic substitution of electron-deficient aryl halides and phenols and is mediated by potassium fluoride/Clinoptilolite (KF/CP) in dimethyl sulfoxide (DMSO). The approach affords good to excellent yields of the arylated products without the need for additional cation capture. The solid base is also efficient in the Ullmann ether synthesis. A new, inexpensive solid base for the synthesis of diaryl ethers has been developed. Clinoptilolite, a natural zeolite with a high tendency for cation capture, combined with potassium fluoride, provides an efficientsolid base for the deprotonation of phenols in nucleophilic reactions. The same solid base acts as a reliable base for the copper-catalyzed synthesis of diaryl ethers. Copyright

Halopyridyl triazolinone herbicides and herbicidal use thereof

Disclosed are herbicidal halopyridyl triazolinones, herbicidal compositions comprising the halopyridyl triazolinones, and herbicidal use of the compounds and compositions. Such compounds and compositions are useful as both preemergence and postemergence herbicides in a variety of crops.

Process of improving activity of herbicides and fertilizers using N-(2-hydroxyethyl)-acetamide or -propanamide

The invention is related to the use of certain water-soluble compounds known as such and having the Formula for the modulation of membrane dependent metabolism processes within living cells, in particular with relation to transport phenomena and cell procedures which are induced or influenced by active agents supplied from outside the cell, products containing these substances for the above described uses and processes using these products.