18366-44-4

Basic information

• Product Name: 1-Propanol, 3-[(1,1-diMethylethyl)aMino]-
• Synonyms: 1-Propanol, 3-[(1,1-diMethylethyl)aMino]-;3-(tert-butylamino)-1-propanol;3-(Tert-Butylamino)Propan-1-Ol(WX640199)
• CAS NO: 18366-44-4
• Molecular Formula: C₇H₁₇NO
• Molecular Weight: 131.21598
• Mol File: 18366-44-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Propanol, 3-[(1,1-diMethylethyl)aMino]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanol, 3-[(1,1-diMethylethyl)aMino]-(18366-44-4)
• EPA Substance Registry System: 1-Propanol, 3-[(1,1-diMethylethyl)aMino]-(18366-44-4)

Safety Data

• Hazardous Substances Data: 18366-44-4(Hazardous Substances Data)

Usage

Uses

3-(tert-Butylamino)propan-1-ol is used in the preparation of a compound liquid waste gas desulfurization agent to remove organic and inorganic S from gases (natural gas, coal gas, biogas, industrial waste gas, refinery gas).

Synthesis Reference(s)

Tetrahedron Letters, 35, p. 761, 1994 DOI: 10.1016/S0040-4039(00)75811-4

Upstream product

• 503-30-0 trimethylene oxide 
• 75-64-9 tert-butylamine 
• 169269-01-6 tert-Butyl-(3-hydroxy-propyl)-carbamic acid tert-butyl ester 
• 22675-81-6 N-(tert-butyl)propan-1-amine 
• 21539-55-9 methyl 3-(N-tert-butylamino)propanoate 
• 627-18-9 1-bromo-3-propanol 
• 627-30-5 1-chloro-3-hydroxypropane 
• 71970-55-3 3-tert-butylamino-acrylaldehyde 
• 1462-98-2 ethyl 3-(tert-butylamino)propanoate 
• 169268-94-4 Allyl-tert-butyl-carbamic acid tert-butyl ester 
• 16486-68-3 N-allyl(tert-butyl)amine 

Downstream Products

• 130613-90-0 2-Benzyl-3-tert-butyl-[1,3,2]oxazaphosphinane 2-oxide 

Relevant articles and documents

Platinum-Catalyzed, Terminal-Selective C(sp3)-H Oxidation of Aliphatic Amines

This Communication describes the terminal-selective, Pt-catalyzed C(sp3)-H oxidation of aliphatic amines without the requirement for directing groups. CuCl2 is employed as a stoichiometric oxidant, and the reactions proceed in high yield at Pt loadings as low as 1 mol%. These transformations are conducted in the presence of sulfuric acid, which reacts with the amine substrates in situ to form ammonium salts. We propose that protonation of the amine serves at least three important roles: (i) it renders the substrates soluble in the aqueous reaction medium; (ii) it limits binding of the amine nitrogen to Pt or Cu; and (iii) it electronically deactivates the C-H bonds proximal to the nitrogen center. We demonstrate that this strategy is effective for the terminal-selective C(sp3)-H oxidation of a variety of primary, secondary, and tertiary amines.

Mild LIBF4-Promoted Aminolysis of Oxetanes

LiBF4 in acetonitrile efficiently catalyzes the aminolysis of trimethylene oxide and 2-octyl oxetane under mild conditions (r.t. or 80 deg C) to give the corresponding γ-amino alcohols in very good yields.