16486-68-3

Basic information

• Product Name: 2-Propen-1-amine, N-(1,1-dimethylethyl)-
• Synonyms: 2-Propen-1-amine, N-(1,1-dimethylethyl)-;N-tert-butylprop-2-en-1-aMine;N-Allyl-N-tert-butylaMine;t-Butyl allylamine;N-allyl(tert-butyl)amine
• CAS NO: 16486-68-3
• Molecular Formula: C₇H₁₅N
• Molecular Weight: 113.2007
• Mol File: 16486-68-3.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 112°C(lit.)
• Appearance: /
• Density: 0.764±0.06 g/cm3(Predicted)
• Refractive Index: 1.4180-1.4200
• PKA: 9.91±0.29(Predicted)
• CAS DataBase Reference: 2-Propen-1-amine, N-(1,1-dimethylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propen-1-amine, N-(1,1-dimethylethyl)-(16486-68-3)
• EPA Substance Registry System: 2-Propen-1-amine, N-(1,1-dimethylethyl)-(16486-68-3)

Safety Data

• RIDADR: 2733
• HazardClass: 3/8
• PackingGroup: II
• Hazardous Substances Data: 16486-68-3(Hazardous Substances Data)

Usage

Description

2-Propen-1-amine, N-(1,1-dimethylethyl)is an organic compound with the molecular formula C7H15N. It is a secondary N-allylamine, which is a type of amine derivative with an allyl group attached to the nitrogen atom. 2-Propen-1-amine, N-(1,1-dimethylethyl)is characterized by its reactivity and ability to form various chemical structures, making it a versatile building block in organic synthesis.

Uses

Used in Pharmaceutical Industry:
2-Propen-1-amine, N-(1,1-dimethylethyl)is used as a synthetic intermediate for the development of new pharmaceutical compounds. Its unique structure allows it to be a key component in the synthesis of various drug candidates, contributing to the advancement of novel treatments for various medical conditions.
Used in Chemical Research:
In the field of chemical research, 2-Propen-1-amine, N-(1,1-dimethylethyl)is used as a reagent for the synthesis of new spiro-isoquinolinones and monoazabutadiene compounds. These synthesized compounds have potential applications in various areas, including pharmaceuticals, materials science, and chemical engineering.
Used in Material Science:
The compound's ability to form complex structures makes it a valuable asset in material science. 2-Propen-1-amine, N-(1,1-dimethylethyl)can be used as a building block for the development of new materials with specific properties, such as improved strength, flexibility, or chemical resistance.

Upstream product

• 845464-89-3 1-(2-allyloxyphenyl)hept-2-yn-1-ol 
• 201230-82-2 carbon monoxide 
• 75-64-9 tert-butylamine 
• 106-95-6 allyl bromide 
• 107-05-1 3-chloroprop-1-ene 
• 107-02-8 acrolein 

Downstream Products

• 84053-73-6 N-Allyl-N-tert.-butyl-β-methyl-zimtsaeureamid 

Relevant articles and documents

Development of a Scalable and Safer Synthesis of Diazeniumdiolates

Although diazeniumdiolates (DAZDs) and the synthetic methods to access DAZDs were discovered over 50 years ago, the current methodology is not safe, has a limited substrate scope, and is not amenable to large-scale production. For example, a recent investigation utilizing the standard methodology to prepare DAZDs resulted in two unexpected explosions, highlighting the need for safer and more practical chemistry. Recently, we have reported a general, scalable, safer, and high-yielding methodology adaptable to large-scale synthesis of diazeniumdiolates in water using a calcium hydroxide base. Herein, we report the full account for the development of the reaction. The merit of this strategy is evidenced by the highly efficient and safer preparation of a key DAZD intermediate, on the kilogram scale, needed for the preparation of MK-8150 (1), a novel O2-alkylated diazeniumdiolate NO donor under investigation as a potent and significant blood-pressure-lowering drug candidate.

Photoinduced radical-initiated carboxylative cyclization of allyl amines with carbon dioxide

Visible light-promoted CO2 upgrading: a highly efficient and metal-free photochemical method for the carboxylative cyclization of allyl amines with CO2 is reported to prepare perfluoroalkylated oxazolidinones with high efficiency under ambient conditions by using perfluoroalkyl iodides as radical sources.

PRODUCTION METHOD FOR 2-ALKENYLAMINE COMPOUND

Provided is a method for producing a 2-alkenylamine compound efficiently and at low cost, using a primary or secondary amine compound and a 2-alkenyl compound as the starting materials therefor. The 2-alkenyleamine compound is produced by 2-alkenylating a primary or secondary amine compound, using a specified 2-alkenylating agent and in the presence of a catalyst comprising a complexing agent and a transition metal precursor stabilized by a monovalent anionic five-membered conjugated diene.