183670-73-7

Upstream product

• 2666-93-5 (S)-Leu-OMe 
• 501082-72-0 Boc-Tyr(2,6-Cl₂Bzl)-Gly-Gly-Phe-OH 
• 501082-71-9 Boc-Tyr(2,6-Cl₂Bzl)-Gly-Gly-Phe-OMe 
• 501082-79-7 Boc-Tyr(2,6-Cl₂Bzl)-Gly-Gly-Phe-Leu-OMe 

Downstream Products

• 501083-16-5 estrone-3-O-CH₂CO-Tyr(2,6-dichlorobenzyl)-Gly-Gly-Phe-Leu-OMe 
• 501083-25-6 C₅₆H₆₇Cl₂N₅O₁₀ 
• 501083-43-8 C₄₉H₆₃N₅O₁₀ 
• 501083-34-7 estrone-3-O-CH₂CO-Tyr-Gly-Gly-Phe-Leu-OMe 
• 501083-33-6 estrone-3-O-CH₂CO-Tyr-Gly-Gly-Phe-Leu-OH 

Relevant academic research and scientific papers

Studies on the synthesis of estrogen-GHRPS linkers

A series of linkers consisted of estrone, estradiol, and GHRPS (growth hormone releasing peptides) were prepared with carboxyl-methyl or succinyl as the conjugated group. As a protective group in the side chain of Tyr, the Dcb (2,6-dichlorobenzyl) in the intermediates which is unstable to HF can be removed in high yield in the presence of Pd/C (10%), H2, and 4.4% formic acid in methanol.