501082-79-7

Upstream product

• 19240-24-5 N--L-3-phenylalanine methyl ester hydrochloride 
• 61131-29-1 N-glycyl>-L-3-phenylalanine methyl ester hydrochloride 
• 501082-71-9 Boc-Tyr(2,6-Cl₂Bzl)-Gly-Gly-Phe-OMe 
• 2666-93-5 (S)-Leu-OMe 
• 501082-72-0 Boc-Tyr(2,6-Cl₂Bzl)-Gly-Gly-Phe-OH 
• 63631-32-3 (S)-methyl 12-benzyl-2,2-dimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oate 
• 106624-70-8 methyl (2S)-2-[[2-(t-butoxycarbonylamino)acetyl]amino]-3-phenylpropanoate 

Downstream Products

• 58822-25-6 Leu-enkephalin 
• 501083-33-6 estrone-3-O-CH₂CO-Tyr-Gly-Gly-Phe-Leu-OH 
• 501083-34-7 estrone-3-O-CH₂CO-Tyr-Gly-Gly-Phe-Leu-OMe 
• 501083-16-5 estrone-3-O-CH₂CO-Tyr(2,6-dichlorobenzyl)-Gly-Gly-Phe-Leu-OMe 
• 501082-88-8 C₅₈H₇₁Cl₂N₅O₁₀ 
• 501083-43-8 C₄₉H₆₃N₅O₁₀ 
• 501083-25-6 C₅₆H₆₇Cl₂N₅O₁₀ 
• 501082-91-3 2-[2-(2-{2-[2-tert-butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid 3-hydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl ester 
• 183670-73-7 H-Tyr(DCB)-Gly-Gly-Phe-Leu-OMe 
• 63441-70-3 Leu-enkephalin methyl ester 
• 143050-69-5 Boc-Tyr(CLz)-Gly-Gly-Phe-Leu-OH 

Relevant academic research and scientific papers

Studies on the synthesis and anti-Osteoporosis of estrogen-GHRPs linkers.

The linkers of estrogen-GHRPs were prepared by the combination of estradiol, estrone, TyrGlyGlyPheLeuOH, and TyrGlyGlyPheLeuOH. Their anti-osteoporosis effect was evaluated by analyzing the data, for instance the weight of the body, femur, femur ash, the content of calcium and phosphor in the femur, the content of calcium and ALP activity in the serum, obtained from the corresponding bioassay in vivo. The results indicated that the anti-osteoporosis potency for estradiol, estrone, TyrGlyGlyPheLeuOH and TyrGlyGlyPheLeuNH(2) may be totally enhanced each other via the corresponding linkers.

Studies on the synthesis of estrogen-GHRPS linkers

A series of linkers consisted of estrone, estradiol, and GHRPS (growth hormone releasing peptides) were prepared with carboxyl-methyl or succinyl as the conjugated group. As a protective group in the side chain of Tyr, the Dcb (2,6-dichlorobenzyl) in the intermediates which is unstable to HF can be removed in high yield in the presence of Pd/C (10%), H2, and 4.4% formic acid in methanol.