18371-09-0

Basic information

• Product Name: 4-[(E)-(4-Chlorophenyl)diazenyl]benzene-1,3-diamine
• Synonyms: 4-[(E)-(4-Chlorophenyl)diazenyl]benzene-1,3-diamine
• CAS NO: 18371-09-0
• Molecular Formula: C₁₂H₁₁ClN₄
• Molecular Weight: 246.69554
• Mol File: 18371-09-0.mol
• Article Data: 2

Chemical Properties

• Melting Point: 158-158.5 °C(Solv: ethanol (64-17-5))
• Boiling Point: 470.0±40.0 °C(Predicted)
• Appearance: /
• Density: 1.36±0.1 g/cm3(Predicted)
• PKA: 3.01±0.10(Predicted)
• CAS DataBase Reference: 4-[(E)-(4-Chlorophenyl)diazenyl]benzene-1,3-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(E)-(4-Chlorophenyl)diazenyl]benzene-1,3-diamine(18371-09-0)
• EPA Substance Registry System: 4-[(E)-(4-Chlorophenyl)diazenyl]benzene-1,3-diamine(18371-09-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 18371-09-0(Hazardous Substances Data)

Upstream product

• 2028-74-2 p-chlorobenzenediazonium chloride 
• 17025-58-0 m-phenylenediamine hydrochloride 
• 108-45-2 m-phenylenediamine 
• 106-47-8 4-chloro-aniline 
• 17333-85-6 4-chlorophenyldiazonium salt 
• 541-69-5 m-phenylenediamine dihydrochloride 

Downstream Products

• 75953-52-5 6-Amino-2-(4-chloro-phenyl)-2H-benzo[1,2,4]triazin-3-one 
• 75953-44-5 [4-(4-Chloro-phenylazo)-3-ethoxycarbonylamino-phenyl]-carbamic acid ethyl ester 
• 40655-09-2 2-(4-chloro-phenyl)-2H-benzo[1,2,3]triazol-5-ylamine 

Relevant articles and documents

APPLICATION OF FLUORESCENT TRIAZOLES TO ANALYTICAL CHEMISTRY. III. FLUORESCENCE CHARACTERISTICS OF 2-PHENYLBENZOTRIAZOLYL-5-AMINE DERIVATIVES AS FLUORESCENT PROBES

2-Phenylbenzotriazole derivatives with a COCH3 or NH2 group on the 2-phenyl ring were synthesized and found to be applicable as fluorescent hydrophobic probes.The fluorescence intensities of these compounds, which were intense in non-polar solvents, were dramatically quenched in polar solvents.In particular, 2-(4-acetylphenyl)-2H-benzotriazolyl-5-amine (7) showed a much higher ratio of the fluorescence intensity in the organic solvent to that in water (Fo/Fw) than 8-anilino-1-naphthalenesulfonate (ANS): The Fo/Fw values of 7 were 470 for dioxane and 440 for acetone, while those of ANS were 100 for dioxane and 90 for acetone.We modified compound 7 to obtain water-soluble probes for use in drug-protein binding studies and examined the interaction of these probes with human serum albumin (HSA).All the compounds, which were practically non-fluorescent in the buffer solution, bound to HSA and fluoresced.Keywords: 2-phenylbenzotriazolyl-5-amine; fluorescence characteristies; solvent effect; fluorescent probe; protein binding