40655-09-2

Basic information

• Product Name: 2-(4-CHLORO-PHENYL)-2H-BENZOTRIAZOL-5-YLAMINE
• Synonyms: ART-CHEM-BB B025248;ASISCHEM T30976;2-(4-CHLORO-PHENYL)-2H-BENZOTRIAZOL-5-YLAMINE;AKOS BB-8211;TIMTEC-BB SBB009772;[2-(4-chlorophenyl)benzotriazol-5-yl]amine;2-(4-chlorophenyl)-2H-1,2,3-benzotriazol-5-amine;2-(4-chlorophenyl)-5-benzotriazolamine
• CAS NO: 40655-09-2
• Molecular Formula: C₁₂H₉ClN₄
• Molecular Weight: 244.68
• Mol File: 40655-09-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-CHLORO-PHENYL)-2H-BENZOTRIAZOL-5-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-CHLORO-PHENYL)-2H-BENZOTRIAZOL-5-YLAMINE(40655-09-2)
• EPA Substance Registry System: 2-(4-CHLORO-PHENYL)-2H-BENZOTRIAZOL-5-YLAMINE(40655-09-2)

Safety Data

• Hazardous Substances Data: 40655-09-2(Hazardous Substances Data)

Usage

Class

Organic compound, benzotriazoles

Common Uses

UV-absorber in plastics, coatings, polymers, personal care products (e.g. sunscreen, skincare)

Functionality

Absorbs ultraviolet radiation, protecting materials from degradation caused by UV exposure

Potential Applications

Pharmaceutical industry (anti-inflammatory, antioxidant properties)

Upstream product

• 108-45-2 m-phenylenediamine 
• 541-69-5 m-phenylenediamine dihydrochloride 
• 17333-85-6 4-chlorophenyldiazonium salt 
• 18371-09-0 4-(4-chloro-phenylazo)-m-phenylenediamine 
• 97-00-7 1-chloro-2,4-dinitro-benzene 
• 106-47-8 4-chloro-aniline 
• 1073-70-7 4-chlorophenylhydrazine hydrochloride 

Downstream Products

• 945528-17-6 N-(2-(4-chlorophenyl)-2H-benzo[d][1,2,3]triazol-5-yl)acetamide 
• 352344-36-6 N-(2-(4-chlorophenyl)-2hbenzo[d][1,2,3]triazol-5-yl)isobutyramide 

Relevant articles and documents

Discovery and SAR of 2-arylbenzotriazoles and 2-arylindazoles as potential treatments for Duchenne muscular dystrophy

Families of 2-arylbenzotriazoles and 2-arylindazoles that show positive effects in screens predictive of endogenous utrophin upregulation have been identified. Synthesis and structure-activity relationships are described leading to compounds with attractive in vitro profiles.

APPLICATION OF FLUORESCENT TRIAZOLES TO ANALYTICAL CHEMISTRY. III. FLUORESCENCE CHARACTERISTICS OF 2-PHENYLBENZOTRIAZOLYL-5-AMINE DERIVATIVES AS FLUORESCENT PROBES

2-Phenylbenzotriazole derivatives with a COCH3 or NH2 group on the 2-phenyl ring were synthesized and found to be applicable as fluorescent hydrophobic probes.The fluorescence intensities of these compounds, which were intense in non-polar solvents, were dramatically quenched in polar solvents.In particular, 2-(4-acetylphenyl)-2H-benzotriazolyl-5-amine (7) showed a much higher ratio of the fluorescence intensity in the organic solvent to that in water (Fo/Fw) than 8-anilino-1-naphthalenesulfonate (ANS): The Fo/Fw values of 7 were 470 for dioxane and 440 for acetone, while those of ANS were 100 for dioxane and 90 for acetone.We modified compound 7 to obtain water-soluble probes for use in drug-protein binding studies and examined the interaction of these probes with human serum albumin (HSA).All the compounds, which were practically non-fluorescent in the buffer solution, bound to HSA and fluoresced.Keywords: 2-phenylbenzotriazolyl-5-amine; fluorescence characteristies; solvent effect; fluorescent probe; protein binding