40655-09-2

Usage

Class

Organic compound, benzotriazoles

Common Uses

UV-absorber in plastics, coatings, polymers, personal care products (e.g. sunscreen, skincare)

Functionality

Absorbs ultraviolet radiation, protecting materials from degradation caused by UV exposure

Potential Applications

Pharmaceutical industry (anti-inflammatory, antioxidant properties)

Upstream product

• 108-45-2 m-phenylenediamine 
• 97-00-7 1-chloro-2,4-dinitro-benzene 
• 106-47-8 4-chloro-aniline 
• 1073-70-7 4-chlorophenylhydrazine hydrochloride 
• 541-69-5 m-phenylenediamine dihydrochloride 
• 17333-85-6 4-chlorophenyldiazonium salt 
• 18371-09-0 4-(4-chloro-phenylazo)-m-phenylenediamine 

Downstream Products

• 945528-17-6 N-(2-(4-chlorophenyl)-2H-benzo[d][1,2,3]triazol-5-yl)acetamide 
• 352344-36-6 N-(2-(4-chlorophenyl)-2hbenzo[d][1,2,3]triazol-5-yl)isobutyramide 

Relevant academic research and scientific papers

Discovery and SAR of 2-arylbenzotriazoles and 2-arylindazoles as potential treatments for Duchenne muscular dystrophy

Families of 2-arylbenzotriazoles and 2-arylindazoles that show positive effects in screens predictive of endogenous utrophin upregulation have been identified. Synthesis and structure-activity relationships are described leading to compounds with attractive in vitro profiles.

TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY

There are disclosed compound of Formula (I) or (II) wherein A1, A2, A3, A4and A5, which may be the same or different, represent N or CR1, R9 represents - L -R3, in whi

APPLICATION OF FLUORESCENT TRIAZOLES TO ANALYTICAL CHEMISTRY. III. FLUORESCENCE CHARACTERISTICS OF 2-PHENYLBENZOTRIAZOLYL-5-AMINE DERIVATIVES AS FLUORESCENT PROBES

2-Phenylbenzotriazole derivatives with a COCH3 or NH2 group on the 2-phenyl ring were synthesized and found to be applicable as fluorescent hydrophobic probes.The fluorescence intensities of these compounds, which were intense in non-polar solvents, were dramatically quenched in polar solvents.In particular, 2-(4-acetylphenyl)-2H-benzotriazolyl-5-amine (7) showed a much higher ratio of the fluorescence intensity in the organic solvent to that in water (Fo/Fw) than 8-anilino-1-naphthalenesulfonate (ANS): The Fo/Fw values of 7 were 470 for dioxane and 440 for acetone, while those of ANS were 100 for dioxane and 90 for acetone.We modified compound 7 to obtain water-soluble probes for use in drug-protein binding studies and examined the interaction of these probes with human serum albumin (HSA).All the compounds, which were practically non-fluorescent in the buffer solution, bound to HSA and fluoresced.Keywords: 2-phenylbenzotriazolyl-5-amine; fluorescence characteristies; solvent effect; fluorescent probe; protein binding