183741-98-2

Basic information

• Product Name: Pyrido[3,4-d]pyrimidin-4(1H)-one, 6-methoxy-
• CAS NO: 183741-98-2
• Molecular Formula: C8H7N3O2
• Mol File: 183741-98-2.mol

Chemical Properties

• Boiling Point: 369.7±52.0 °C(Predicted)
• Density: 1.46±0.1 g/cm3(Predicted)
• CAS DataBase Reference: Pyrido[3,4-d]pyrimidin-4(1H)-one, 6-methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrido[3,4-d]pyrimidin-4(1H)-one, 6-methoxy-(183741-98-2)
• EPA Substance Registry System: Pyrido[3,4-d]pyrimidin-4(1H)-one, 6-methoxy-(183741-98-2)

Safety Data

• Hazardous Substances Data: 183741-98-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Pyrido[3,4-d]pyrimidin-4(1H)-one, 6-methoxyis used as a potential drug candidate for its anticancer and antiviral properties, aiming to develop novel therapeutic agents for the treatment of various diseases.
Used in Medicinal Chemistry Research:
Pyrido[3,4-d]pyrimidin-4(1H)-one, 6-methoxyis used as a research compound for understanding its pharmacological properties and exploring its potential applications in drug discovery and development.
Used in Pharmacology Studies:
Pyrido[3,4-d]pyrimidin-4(1H)-one, 6-methoxyis used as a subject of pharmacological investigations to evaluate its efficacy, safety, and mechanism of action in the context of its potential therapeutic uses.

Upstream product

• 58483-95-7 5‐amino‐2‐chloropyridine‐4‐carboxylic acid 
• 67-56-1 methanol 
• 124-41-4 sodium methylate 
• 171178-47-5 6-chloro-3H-pyrido[3,4-d]pyrimidin-4-one 
• 183741-86-8 5-((tert-butoxycarbonyl)amino)-2-methoxyisonicotinic acid 
• 183741-80-2 tert-butyl N-(6-methoxypyridin-3-yl)carbamate 
• 6628-77-9 6-methoxy-pyridin-3-ylamine 
• 3473-63-0 formamidine acetic acid 
• 183741-91-5 5‐amino‐2‐methoxypyridine‐4‐carboxylic acid 

Relevant articles and documents

HETEROCYCLIC INHIBITORS OF TYROSINE KINASE

The present disclosure relates to heterocyclic compounds and methods which may be useful as inhibitors of HER2 or EGFR for the treatment or prevention of disease, including cancer.

Discovery and Characterization of the Potent and Highly Selective (Piperidin-4-yl)pyrido[3,2- d]pyrimidine Based in Vitro Probe BAY-885 for the Kinase ERK5

The availability of a chemical probe to study the role of a specific domain of a protein in a concentration- and time-dependent manner is of high value. Herein, we report the identification of a highly potent and selective ERK5 inhibitor BAY-885 by high-throughput screening and subsequent structure-based optimization. ERK5 is a key integrator of cellular signal transduction, and it has been shown to play a role in various cellular processes such as proliferation, differentiation, apoptosis, and cell survival. We could demonstrate that inhibition of ERK5 kinase and transcriptional activity with a small molecule did not translate into antiproliferative activity in different relevant cell models, which is in contrast to the results obtained by RNAi technology.

IDENTIFICATION AND USE OF ERK5 INHIBITORS

The present invention covers heterocyclic compounds of general formula (I) in which T, U, Y, Z, R1 and R3 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer disorders, as a sole agent or in combination with other active ingredients.

Synthesis of 6-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones via directed lithiation of 2-substituted 5-aminopyridine derivatives

Directed lithiation of Boc or pivaloyl derivatives of 2-substituted 5-aminopyridines with BuLi-TMEDA in diethyl ether at -10°C gave 4-lithio derivatives which were quenched with CO2 to give the analogous C-4 carboxylic acids. Hydrolysis of the protecting groups with either TFA or aqueous KOH gave 2-substituted 5-aminopyridine-4-carboxylic acids which were converted to 6-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones by reaction with formamide or, more optimally, formamidine acetate. Boc protected aminopyridines provided the best overall results, with synthesis of these derivatives best achieved by direct reaction of the aminopyridine with di-tert-butyl dicarbonate in the absence of added base.