18392-50-2

Upstream product

• 24756-10-3 3-(2-(2-nitrophenyl)hydrazineylidene)pentane-2,4-dione 
• 36639-66-4 pyruvaldehyde-1-(2-nitro-phenylhydrazone) 
• 119-66-4 2-nitrobenzenediazonium chloride 
• 1694-29-7 3-chloropentane-2,4-dione 
• 67-66-3 chloroform 
• 7782-50-5 chlorine 

Downstream Products

• 81585-46-8 2-acetyl-4-(2-nitrophenyl)-5-N-(nitrosoimino)-Δ²-1,3,4-thiadiazoline 

Relevant academic research and scientific papers

A STUDY OF THE EFFECT OF NITRO GROUP IN THE SYNTHESIS OF PYRAZOLES AND THIADIAZOLINES FROM HYDRAZIDOYL HALIDES.

The reaction of C-acetyl-N-(2-nitrophenyl)hydrazidoyl chloride 5 with sodium ethoxide and ethyl cyanoacetate yields only one isolable product identified as ethyl 1-(2-nitrophenyl)-3-acetyl-5-aminopyrazole-4-carboxylate 6, in contrast to the C-phenyl-N-(2-nitrophenyl)hydrazidoyl bromide analog 1.The nitrilimine derived from 5 adds to the C=C double bond of the enol tautomers of acetylacetone and dibenzoylmethane and gives the corresponding pyrazole derivatives 7 and 8, which upon hydrazinolysis yield 11 and 12, respectively.These results indicate that the ortho nitro group in 5 seems to have no influence on the course of the reactions of 5 with dipolarophilic reagents.Nucleophilic substitution of the halogen atom in 5 by thiocyanate anion and morpholine seems to proceed in a normal way as other hydrazidoyl halides to give the corresponding thiadiazoline and amidrazone derivatives 13 and 19 respectively.

Method of treating animals and formulations therefor

This invention relates to a new method of using and formulations of pyruvoyl chloride phenylhydrazones of the formula SPC1 Wherein Y is selected from the group consisting of chloro, bromo, nitro and trifluoromethyl and Y' has the same meaning as Y and in addition hydrogen, that have been found to be effective broad spectrum anthelmintics for suppressing parasitic worms in animals. The compounds are readily prepared by conventional chemical reactions.