183947-33-3

Upstream product

• 100-39-0 benzyl bromide 
• 160238-67-5 (2R,3S,4R,6S)-2-isopropyl-3,6-dimethoxy-3,4,5,6-tetrahydro-2H-pyran-4-ol 
• 160238-68-6 (2R,3S,4R,6S)-4-benzyloxy-2-isopropyl-3,6-dimethoxy-3,4,5,6-tetrahydro-2H-pyran 
• 98-88-4 benzoyl chloride 
• 160238-69-7 (3R,4R,5R)-5-benzyloxy-6-(1,3-dithian-2-yl)-4-methoxy-2-methyl-3-hexanol 

Downstream Products

• 183947-41-3 [2R,2(2R,3S,6R,8S,8(3S),9R),3E,6R,7S,9R,10S,11R]-11-acetoxy-9-benzyloxy-2-{3,9-dimethyl-8-[3-(2-methyl-1,3-dithian-2-yl)butyl]-1,7-dioxaspiro[5.5]undecan-2-yl}-10-methoxy-7-(4-methoxybenzyl)oxy-6,12-dimethyl-3-tridecen-5-one 
• 183947-45-7 Acetic acid (1R,2S,3R,5S,6R,7S,10R)-3-benzyloxy-10-[(2S,3S,6R,8S,9R)-3,9-dimethyl-8-((S)-3-methyl-4-oxo-pentyl)-1,7-dioxa-spiro[5.5]undec-2-yl]-1-isopropyl-2-methoxy-5-(4-methoxy-benzyloxy)-6-methyl-7-triethylsilanyloxy-undecyl ester 
• 183947-42-4 Acetic acid (1R,2S,3R,5S,6R,10R)-3-benzyloxy-10-{(2S,3S,6R,8S,9R)-3,9-dimethyl-8-[(S)-3-(2-methyl-[1,3]dithian-2-yl)-butyl]-1,7-dioxa-spiro[5.5]undec-2-yl}-1-isopropyl-2-methoxy-5-(4-methoxy-benzyloxy)-6-methyl-7-oxo-undecyl ester 
• 183947-35-5 Benzoic acid (1R,2S,3R,5S,6R)-3-benzyloxy-1-isopropyl-2-methoxy-5-(4-methoxy-benzyloxy)-6-(methoxy-methyl-carbamoyl)-heptyl ester 
• 183947-34-4 Benzoic acid (1R,2S,3R,5S,6R)-3-benzyloxy-6-carboxy-1-isopropyl-2-methoxy-5-(4-methoxy-benzyloxy)-heptyl ester 
• 160238-71-1 (3(2R,3S,5R,6S,7R),4R)-3-(7-benzoyloxy-5-benzyloxy-3-hydroxy-6-methoxy-2,8-dimethyl-1-oxononyl)-4-isopropyl-2-oxazolidinone 
• 183947-32-2 (3R,4S,6R,7R,8R)-6-Benzyloxy-8-hydroxy-7-methoxy-4-(4-methoxy-benzyloxy)-3,9-dimethyl-decan-2-one 
• 160238-72-2 <3(2R,3S,5R,6S,7R),4R>-3-(7-benzoyloxy-5-benzyloxy-6-methoxy-3-(4-methoxybenzyl)oxy-2,8-dimethyl-1-oxononyl)-4-isopropyl-2-oxazolidinone 
• 109946-35-2 tautomycin 
• 160238-70-0 (1R,2S,3R)-3-benzyloxy-4-formyl-1-isopropyl-2-methoxybutyl benzoate 

Relevant academic research and scientific papers

Total synthesis of (+)-tautomycin

A convergent stereocontrolled total synthesis of (+)-tautomycin (1), a specific inhibitor of protein serine/threonine phosphatases, has been achieved through an esterification of the C1.-C7. fragment A'74 with the C1-C26 fragment B'76 by a modified Yamaguchi method and an aldol reaction of the C17-C26 fragment C 5 with the C1-C16 fragment D 6 using LDA as key steps. The fragments 5 and 6 have been constructed in a stereocontrolled manner, respectively.