183954-75-8Relevant academic research and scientific papers
Improvement of the synthesis of immunological carbohydrate vaccines containing the tumour associate antigen CaMBr1
Lay, Luigi,Panza, Luigi,Poletti, Laura,Prosperi, Davide,Canevari, Silvana,Perico, Maria Elisa
, p. 4331 - 4336 (2007/10/03)
The simplified synthesis of a portion of Globo-H hexasaccharide, a saccharide antigen overexpressed by breast cancer cells, and its conjugation to two different immunogenic proteins are described. The conjugated vaccines, evaluated in a preclinical model, showed good immunogenic potential.
Rational design and synthesis of a 1,1-linked disaccharide that is 5 times as active as sialyl Lewis X in binding to E-selectin
Hiruma, Kazumi,Kajimoto, Tetsuya,Weitz-Schmidt, Gabriel,Ollmann, Ian,Wong, Chi-Huey
, p. 9265 - 9270 (2007/10/03)
We describe here a rational design and synthesis of (3-O-carboxymethyl)-β-D-galactopyranosyl α-D-mannopyranoside which is 5 times as active as sialyl Lewis X in binding to E-selectin and also effective against P- and L-selectin. A new method for the 1,1-g
