1840-02-4

Basic information

• Product Name: 4H-1-Benzopyran-4-one, 2-(4-fluorophenyl)-2,3-dihydro-
• CAS NO: 1840-02-4
• Molecular Formula: C15H11FO2
• Molecular Weight: 242.25
• Mol File: 1840-02-4.mol
• Article Data: 23

Chemical Properties

• CAS DataBase Reference: 4H-1-Benzopyran-4-one, 2-(4-fluorophenyl)-2,3-dihydro-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-1-Benzopyran-4-one, 2-(4-fluorophenyl)-2,3-dihydro-(1840-02-4)
• EPA Substance Registry System: 4H-1-Benzopyran-4-one, 2-(4-fluorophenyl)-2,3-dihydro-(1840-02-4)

Safety Data

• Hazardous Substances Data: 1840-02-4(Hazardous Substances Data)

Upstream product

• 533-58-4 2-Iodophenol 
• 459-57-4 4-fluorobenzaldehyde 
• 118-93-4 o-hydroxyacetophenone 
• 140-75-0 para-fluorobenzylamine 
• 1840-01-3 (E)-1-(2-hydroxyphenyl)-3-(4-fluorophenyl)prop-2-en-1-one 
• 1840-01-3 3-(4-fluorophenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one 
• 3798-61-6 1-(4-fluorophenyl)prop-2-yn-1-ol 
• 3327-24-0 1-(2-hydroxyphenyl)-3-(4-methoxyphenyl)-2-propen-1-one 
• 123-11-5 4-methoxy-benzaldehyde 
• 59223-79-9 1-(2-hydroxy-phenyl)-3-(4-fluoro-phenyl)-propan-1-one 
• 108-95-2 phenol 
• 491-37-2 2,3-dihydro-4H-1-benzopyran-4-one 
• 1765-93-1 4-fluoroboronic acid 
• 3055-86-5 3-phenoxypropionitrile 

Downstream Products

• 138846-96-5 4-(4-Fluoro-phenyl)-3,4-dihydro-benzo[b][1,4]dioxepin-2-one 
• 1840-01-3 (E)-1-(2-hydroxyphenyl)-3-(4-fluorophenyl)prop-2-en-1-one 
• 36136-90-0 3-(4-fluorophenyl)-4H-chromen-4-one 
• 1645-21-2 2-(4-fluorophenyl)-4H-chromen-4-one 

Relevant articles and documents

Synthesis of Flavanone and Quinazolinone Derivatives from the Ruthenium-Catalyzed Deaminative Coupling Reaction of 2′-Hydroxyaryl Ketones and 2-Aminobenzamides with Simple Amines

The cationic Ru–H complex [(C6H6)(PCy3)(CO)RuH]+BF4– (1) with 3,4,5,6-tetrachloro-1,2-benzoquinone (L1) was found to be a highly effective catalyst for the deaminative coupling reaction of 2′-hydroxyaryl ketones with simple amines to form 3-substituted flavanone products. The analogous deaminative coupling reaction of 2-aminobenzamides with branched amines directly formed 3,3-disubstituted quinazolinone products. The catalytic method efficiently installs synthetically useful flavanone and quinazolinone core structures without employing any reactive reagents.

Divergent synthesis of flavones and flavanones from 2′-hydroxydihydrochalconesviapalladium(ii)-catalyzed oxidative cyclization

Divergent and versatile synthetic routes to flavones and flavanonesviaefficient Pd(ii) catalysis are disclosed. These Pd(ii) catalyses expediently provide a variety of flavones and flavanones from 2′-hydroxydihydrochalcones as common intermediates, depending on oxidants and additives,viadiscriminate oxidative cyclization sequences involving dehydrogenation, respectively, in a highly atom-economic manner.

Organocatalytic Approach for Assembling Flavanones via a Cascade 1,4-Conjugate Addition/oxa-Michael Addition between Propargylamines with Water

A DBU-catalyzed one-pot cascade reaction of propargylamines and water for the synthesis of flavanones has been developed. This process proceeds via a sequence of 1,4-conjugate addition of water to alkynyl o-quinone methide (o-AQM), followed by the alkyne-allene isomerization and subsequent intramolecular oxa-Michael addition. This strategy provides a convenient method for accessing a broad range of flavanones in good to excellent yields with good functional-group tolerance, in particular, the reactive halo functional groups.