18402-97-6

Basic information

• Product Name: 2-(2-phenyl-2H-1,2,3-triazol-4-yl)tetrahydrofuran-3,4-diol
• CAS NO: 18402-97-6
• Molecular Formula: C₁₂H₁₃N₃O₃
• Molecular Weight: 247.2499
• Mol File: 18402-97-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 517.1°C at 760 mmHg
• Flash Point: 266.5°C
• Density: 1.53g/cm³
• Vapor Pressure: 1.61E-11mmHg at 25°C
• Refractive Index: 1.713
• CAS DataBase Reference: 2-(2-phenyl-2H-1,2,3-triazol-4-yl)tetrahydrofuran-3,4-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-phenyl-2H-1,2,3-triazol-4-yl)tetrahydrofuran-3,4-diol(18402-97-6)
• EPA Substance Registry System: 2-(2-phenyl-2H-1,2,3-triazol-4-yl)tetrahydrofuran-3,4-diol(18402-97-6)

Safety Data

• Hazardous Substances Data: 18402-97-6(Hazardous Substances Data)

Usage

Structure

Tetrahydrofuran derivative containing a 1,2,3-triazole and a phenyl group

Potential applications

Pharmacological and biological applications, antifungal and antiviral properties, drug delivery systems

Unique feature

The compound's structure makes it an interesting candidate for further research into its potential therapeutic uses.

Upstream product

• 6164-71-2 D-allose osazone 
• 7625-23-2 3,6-anhydro-D-glucose 
• 534-97-4 glucosazone 
• 100-63-0 phenylhydrazine 
• 6341-06-6 2-phenyl-4-(D-arabino-1',2',3',4'-tetrahydroxybutyl)-2H-1,2,3-triazole 
• 67-56-1 methanol 
• 35522-79-3 D-arabino-3,6-anhydro-[2]hexosulose-bis-phenylhydrazone 

Downstream Products

• 79726-78-6 4-(2,3-O-isopropylidene-α-D-erythrofuranosyl)-2-phenyl-1,2,3-triazole 
• 97832-39-8 (2S)-3c,4c-diacetoxy-2r-[2-(4-nitro-phenyl)-2H-[1,2,3]triazol-4-yl]-tetrahydro-furan 
• 99801-44-2 4-((3aS)-2,2-dimethyl-(3ar,6ac)-tetrahydro-furo[3,4-d][1,3]dioxol-4t-yl)-2-(4-nitro-phenyl)-2H-[1,2,3]triazole 
• 95707-66-7 (3S)-2c-[2-(4-nitro-phenyl)-2H-[1,2,3]triazol-4-yl]-tetrahydro-furan-3r,4c-diol 

Relevant articles and documents

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Studies on epimeric-D-arabino- and -D-ribo-tetritol-1-yl-2-phenyl-2 h- 1,2,3-triazoles. Synthesis and anomeric configuration of 4-(α- and β-D- erythrofuranosyl)-2-phenyl-2 h-1,2,3-triazole C-nucleoside analogs

Treatment of 4-(D-arabino-tetritol-l-yl)-2-phenyl-2 H-1,2,3-triazole (1) with one mole equivalent of tosyl chloride in pyridine solution, afforded the C-nucleoside analogs, 4-(α-D-erythrofuranosyl)-2-phenyl-2 H- 1,2,3-triazole (2) in 25% yield, as well as the byproduct 4-(4-chloro-4-deoxy-D-arabino- tetritol-l-yl)-2-phenyl-2 H-1,2,3-triazole(3). Treatment of the epimeric 4- (D-ribo-tetritol-l-yl)-2-phenyl-2 H-1,2,3-triazole(8) with tosyl chloride in pyridine solution afforded the anomeric C-nucleoside analogs, 4-(β-D- erythrofuranosyl)-2-phenyl-2 H-1,2,3-triazole (9) in 23% yield. Similar treatment of 8 with trifluoromethanesulfonyl chloride in pyridine solution afforded 9. The structure and anomeric configuration of these compounds were determined by acylation, NMR, NOE, circular dichroism spectroscopy and mass spectrometry.