184027-48-3

Upstream product

• 107-21-1 ethylene glycol 
• 184025-18-1 ciproxifan 
• 315674-93-2 cyclopropyl-{4-[3-(1-trityl-1H-imidazol-4-yl)-propoxy]-phenyl}-methanone 
• 152030-49-4 3-(1-trityl-1H-imidazol-4-yl)propan-1-ol 
• 36116-18-4 cyclopropyl 4-hydroxyphenyl ketone 
• 772-31-6 cyclopropyl(4-fluorophenyl)methanone 

Relevant academic research and scientific papers

Analogues and derivatives of ciproxifan, a novel prototype for generating potent histamine H3-receptor antagonists

Novel derivatives of the highly potent and selective histamine H3-receptor antagonist ciproxifan (3) with different chain lengths as well as with structural variants of the cyclopropyl ketone moiety have been prepared and screened for their antagonist H3-receptor potencies in vitro and in vivo. Some derivatives (2, 6-8, 12) containing other functionalities were effective in vitro in the same (sub)nanomolar concentration range and in vivo in a remarkably low oral dose. (C) 2000 Elsevier Science Ltd.

Imidazole derivatives as histamine receptor H3 (ANT) agonists

Novel imidazole derivatives as histamine receptor H3antagonists and/or agonists, preparation thereof and therapeutical uses thereof. Chemical compounds for use as histamine receptor H3agonists, partial agonists or antagonists, having general formula (Ia) or (Ib), the use thereof for making drugs, and methods for revealing the agonist, partial agonist or antagonist activity of such compounds in vivo, are disclosed.