315674-93-2

Upstream product

• 772-31-6 cyclopropyl(4-fluorophenyl)methanone 
• 152030-49-4 3-(1-trityl-1H-imidazol-4-yl)propan-1-ol 
• 3874-54-2 4-(4-fluorophenyl)-4-oxo-n-butyl chloride 
• 36116-18-4 cyclopropyl 4-hydroxyphenyl ketone 

Downstream Products

• 184027-48-3 4-Hydroxy-1-(4-(3-(1H-imidazol-4-yl)propyloxy)phenyl)butanone ethylene acetal 
• 184025-60-3 FUB 360 
• 184025-18-1 ciproxifan 

Relevant academic research and scientific papers

Convenient procedures for synthesis of ciproxifan, a histamine H3-receptor antagonist

Cyclopropyl 4-(3-(1H-imidazol-4-yl)propyloxy)phenyl methanone (ciproxifan) is a novel reference antagonist for the histamine H3 receptor. Despite the former Mitsunobu reaction the actual key reaction for preparation based on S(N)Ar for acylated fluoroaromatics with an additional cyclization in a one-pot procedure needs no chromatographic purification steps and results in good yields.

Analogues and derivatives of ciproxifan, a novel prototype for generating potent histamine H3-receptor antagonists

Novel derivatives of the highly potent and selective histamine H3-receptor antagonist ciproxifan (3) with different chain lengths as well as with structural variants of the cyclopropyl ketone moiety have been prepared and screened for their antagonist H3-receptor potencies in vitro and in vivo. Some derivatives (2, 6-8, 12) containing other functionalities were effective in vitro in the same (sub)nanomolar concentration range and in vivo in a remarkably low oral dose. (C) 2000 Elsevier Science Ltd.

Novel histamine H3-receptor antagonists with carbonyl-substituted 4-(3-(phenoxy)propyl)-1H-imidazole structures like ciproxifan and related compounds

Novel histamine H3-receptor antagonists possessing a 4-(3-(phenoxy)propyl)-1H-imidazole structure generally substituted in the para-position of the phenyl ring have been synthesized according to Mitsunobu or S(N)Ar reactions. With in vitro and