184291-98-3

Upstream product

• 75-16-1 methylmagnesium bromide 
• 184291-97-2 (+)-(Z)-(2R,3S,4S)-3-(4-methoxybenzyloxy)-2,4-dimethylocta-5,7-dienal 
• 2746-25-0 p-Methoxybenzyl bromide 
• 105-13-5 4-Methoxybenzyl alcohol 
• 184291-36-9 (+)-(Z)-(2S,3S,4S)-3-(4-methoxybenzyloxy)-2,4-dimethylocta-5,7-dien-1-ol 
• 184291-96-1 (+)-tert-butyl-[(Z)-(2S,3S,4S)-3-(4-methoxybenzyloxy)-2,4-dimethylocta-5,7-dienyloxy]dimethylsilane 
• 184291-35-8 tert-Butyl-[(Z)-(2S,3S,4S)-6-iodo-3-(4-methoxy-benzyloxy)-2,4-dimethyl-hex-5-enyloxy]-dimethyl-silane 
• 261968-20-1 (-)-(2R,3R,4S)-5-(tert-butyldimethylsilanyloxy)-3-(4-methoxybenzyloxy)-2,4-dimethylpentanal 
• 184291-95-0 (2S,3S,4S)-1-(tert-butyldimethylsilanyloxy)-3-(4-methoxybenzyloxy)-2,4-dimethyl hex-5-ene 

Downstream Products

• 184291-48-3 (3Z,11Z)-(5S,6S,7R,9S,13S,14S,15S)-14-(tert-Butyl-dimethyl-silanyloxy)-6-(4-methoxy-benzyloxy)-5,7,9,11,13,15-hexamethyl-heptadeca-1,3,11,16-tetraen-8-one 
• 184488-64-0 (Z)-(3R,4S,5S)-4-(4-Methoxy-benzyloxy)-3,5-dimethyl-nona-6,8-dien-2-one 

Relevant academic research and scientific papers

Syntheses of discodermolides useful for investigating microtubule binding and stabilization

Discodermolide is a marine natural product reported to inhibit the proliferation of T cells and exhibit immunosuppresive activity. Total syntheses of the natural antipode of discodermolide and several variants are reported. These studies provide reagents