184292-16-8

Basic information

• Product Name: N-ALLOC-1 6-HEXANEDIAMINE HYDROCHLORIDE
• Synonyms: N-ALLOC-1 6-HEXANEDIAMINE HYDROCHLORIDE;n-alloc-1,6-diaminohexane hydrochloride;N-Alloc-1,6-diaminohexane hydrochloride, Allyl N-(6-aminohexyl)carbamate hydrochloride
• CAS NO: 184292-16-8
• Molecular Formula: C₁₀H₂₀N₂O₂
• Molecular Weight: 236.741
• Mol File: 184292-16-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-ALLOC-1 6-HEXANEDIAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-ALLOC-1 6-HEXANEDIAMINE HYDROCHLORIDE(184292-16-8)
• EPA Substance Registry System: N-ALLOC-1 6-HEXANEDIAMINE HYDROCHLORIDE(184292-16-8)

Safety Data

• WGK Germany: 3
• F: 10-23-34
• Hazardous Substances Data: 184292-16-8(Hazardous Substances Data)

Upstream product

• 124-09-4 1,6-Hexanediamine 
• 2937-50-0 Allyl chloroformate 
• 16308-68-2 allyl phenyl carbonate 

Downstream Products

• 1061361-64-5 C₅₈H₇₈N₈O₉ 
• 1061361-72-5 C₅₈H₇₈N₈O₉ 
• 1061361-68-9 C₅₈H₇₆N₈O₈ 
• 1061361-76-9 C₅₈H₇₆N₈O₈ 
• 184291-86-9 [2S-(2β(3Z,5S,6S,7R,9S,11Z,13S,14S,15S,16Z,18S),3β,4β,5α,6α)]-14,18-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-19-{4-[(1,1-dimethylethyl)dimethylsilyl]oxy}tetrahydro-3,5-dimethyl-6-(phenylthio)-2H-pyran-2-yl-6-[(4-methoxyphenyl)methoxy]-9- 

Relevant articles and documents

Novel method for the synthesis of urea backbone cyclic peptides using new Alloc-protected glycine building units

Cyclization of bioactive peptides, utilizing functional groups serving as natural pharmacophors, is often accompanied with loss of activity. The backbone cyclization approach was developed to overcome this limitation and enhance pharmacological properties. Backbone cyclic peptides are prepared by the incorporation of special building units, capable of forming amide, disulfide and coordinative bonds. Urea bridge is often used for the preparation of cyclic peptides by connecting two amine functionalized side chains.Herewe present urea backbone cyclization as an additional method for the preparation of backbone cyclic peptide libraries. A straightforward method for the synthesis of crystalline Fmoc-Nα [ω-amino(Alloc)-alkyl] glycine building units is presented. A set of urea backbone cyclic Glycogen Synthase Kinase 3 analogs was prepared and assessed for protein kinase B inhibition as anticancer leads. Copyright

Stable helical peptoids via covalent side chain to side chain cyclization

Peptoids are oligomeric N-substituted glycines with potential as biologically relevant compounds. Helical peptoids provide an attractive fold for the generation of protein-protein interaction inhibitors. The generation of helical peptoid folds in organic and aqueous media has been limited to strict design rules, as peptoid-folding is mainly directed via the steric direction of α-chiral side-chains. Here a new methodology is presented to induce helical folds in peptoids with the aid of side chain to side chain cyclization. Cyclic peptoids were generated via solid-phase synthesis and their folding was studied. The cyclization induces significant helicity in peptoids in organic media, aids the folding in aqueous media, and requires the incorporation of only relatively few chiral aromatic side chains. The Royal Society of Chemistry.

Selective synthesis of carbamate protected polyamines using alkyl phenyl carbonates

Utilising alkyl phenyl carbonates, an economical, practical and versatile method for selective Boc, Cbz and Alloc protection of polyamines has been developed. This method allows Boc, Cbz and Alloc protection of primary amines in the presence of secondary amines by reaction of the polyamines with the alkyl phenyl carbonates. Also, this method allows mono carbamate protection of simple symmetrical aliphatic α,ω-alkanediamines in high yields with respect to the diamine. Finally, the method allows selective carbamate protection of a primary amine located on a primary carbon in the presence of a primary amine located on a secondary or a tertiary carbon in excellent yields.