184293-94-5

Basic information

• Product Name: Carbamic acid, 6-(4-O-.beta.-D-galactopyranosyl-.beta.-D-glucopyranosyl)oxyhexyl-, phenylmethyl ester
• Synonyms: Carbamic acid, 6-(4-O-.beta.-D-galactopyranosyl-.beta.-D-glucopyranosyl)oxyhexyl-, phenylmethyl ester
• CAS NO: 184293-94-5
• Molecular Formula: C₂₆H₄₁NO₁₃
• Molecular Weight: 0
• Mol File: 184293-94-5.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Carbamic acid, 6-(4-O-.beta.-D-galactopyranosyl-.beta.-D-glucopyranosyl)oxyhexyl-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, 6-(4-O-.beta.-D-galactopyranosyl-.beta.-D-glucopyranosyl)oxyhexyl-, phenylmethyl ester(184293-94-5)
• EPA Substance Registry System: Carbamic acid, 6-(4-O-.beta.-D-galactopyranosyl-.beta.-D-glucopyranosyl)oxyhexyl-, phenylmethyl ester(184293-94-5)

Safety Data

• Hazardous Substances Data: 184293-94-5(Hazardous Substances Data)

Upstream product

• 501-53-1 benzyl chloroformate 
• 4048-33-3 6-amino-1-hexanol 
• 5160-10-1 2,3,6-tetra-O-acetyl-4-O-(2',3',4',6'-tetra-O-acetyl-β-D-galactopyranosyl)-D-glucopyranosylbromide 
• 3616-19-1 1',2',3',6',2,3,4,6-octa-O-acetyl-β-D-lactose 
• 4753-07-5 2,3,6,2',3',4',6'-hepta-O-acetyl-lactosyl bromide 
• 17996-12-2 N-benzyloxycarbonyl-6-amino-1-hexanol 

Relevant articles and documents

METHOD FOR PREPARING 6-AMINOHEXYL LACTOSIDE-NOTA CONJUGATE

The present invention provides a method for preparing a 6-aminohexyl lactoside-NOTA conjugate. The preparation method comprises brominating perbenzoylated lactose with hydrobromic acid; glycosylating 6-azidohexanol to obtain 6-azidohexyl perbenzoyl lactoside; and deprotecting this precursor in two steps to obtain 6-aminohexyl lactoside and conjugating 6-aminohexyl lactoside to NCS-benzyl-NODA GA (i.e. 2,2′-(7-(1-carboxy-4-((4-isothiocyanate benzyl) amino)-4-oxobutyl)-1,4,7-triazonane-1,4-diyl) diacetic acid) in triethyl amine as an alkaline solvent, to obtain a 6-aminohexyl lactoside-NCS-benzyl-NODA GA conjugate. In this novel preparation method, no deglycosylated side product is produced, such that the yield is considerably increased to 46%. Therefore, the method is suitable for future massive production since the requirement for repeated preparations for massive production is reduced, and the impurities produced in the previously scaled-up preparation process are not present.