184376-55-4

Upstream product

• 67-56-1 methanol 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 50373-10-9 methyl ecgonidine 
• 2417-95-0 p-tolyllithium 
• 223384-69-8 3α-(4-methylphenyl)-2β-(3'-methyl-1',2',4'-oxadiazol-5'-yl)tropane 

Relevant academic research and scientific papers

Synthesis and binding affinities of 2β-(3-iodoallyloxycarbonyl)-3β-(4-substituted-aryl)tropane analogues as ligands for the dopamine transporter studies

Tropane analogues from cocaine, which is known to be one of the most reinforcing and addictive compounds, were designed, synthesized, and characterized for inhibition of presynaptic uptake of dopamine (DA) in brain. Eight new derivatives of 3β-aryl-2β-(3-iodoallyloxycarbonyl)tropanes were synthesized and tested for their potential abilities to displace [3H]2β-carbomethoxy-3β-(4-fluorophenyl)tropane (WIN 35,428) binding to the rat striatal membranes.

Dopamine transporter imaging ligand

The 3α isomer of RTI-55, RTI-352, is an effective in vivo binding ligand that reflects greater selectivity for the dopamine transporter than is observed with RTI-55. In addition, there is also a more rapid achievement of apparent equilibrium in the striat