1844-54-8

Basic information

• Product Name: 2-phenylimidazo[1,2-b]pyridazine
• Synonyms: Imidazo(1,2-b)pyridazine, 2-phenyl-
• CAS NO: 1844-54-8
• Molecular Formula: C₁₂H₉N₃
• Molecular Weight: 195.22
• Mol File: 1844-54-8.mol
• Article Data: 4

Chemical Properties

• Density: 1.21g/cm³
• Refractive Index: 1.674
• CAS DataBase Reference: 2-phenylimidazo[1,2-b]pyridazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenylimidazo[1,2-b]pyridazine(1844-54-8)
• EPA Substance Registry System: 2-phenylimidazo[1,2-b]pyridazine(1844-54-8)

Safety Data

• Hazardous Substances Data: 1844-54-8(Hazardous Substances Data)

Upstream product

• 98-86-2 acetophenone 
• 5469-70-5 3-aminopyridazine 
• 70-11-1 α-bromoacetophenone 

Relevant articles and documents

A comparison between Suzuki cross-coupling reaction and direct arylation in the synthesis of new antibacterial imidazo-pyrazines/pyridazines

Two efficient synthetic routes to preparation of 2,3-diarylimidazo[1,2-a]pyrazines and 2,3-diarylimidazo[1,2-b]pyridazines are described. The procedures involve a Suzuki cross-coupling reaction and a palladium-catalyzed direct arylation at position 3 and

General Method for the Preparation of Electron-Deficient Imidazo[1,2-a]pyridines and Related Heterocycles

A new annulation method for the preparation of the imidazo[1,2-a]pyridine ring system under mild conditions is presented. Treatment of a 2-aminopyridine with a dimethylketal tosylate in acetonitrile at elevated temperature (80-140°C) in the presence of catalytic Sc(OTf)3 provides the imidazo[1,2-a]pyridine product in good yield. The annulation method is broadly applicable to electron-poor 2-aminopyridines and displays a complementary profile to the classic preparation of the imidazo[1,2-a]pyridine ring system by reaction of a bromoketone with electron-rich and -neutral substrates. The scope of the process and mechanistic considerations are discussed.