18442-22-3

Basic information

• Product Name: 7-Bromo-4-chromanone
• Synonyms: 7-Bromo-4-chromanone;7-Bromo Chromonone;7-bromo-2,3-dihydrochromen-4-one;7-Bromo-2,3-dihydro-4H-1-benzopyran-4-one;7-broMo-3,4-dihydro-2H-1-benzopyran-4-one;7-BroMo-4-chroManone 97%;7-Bromochroman-4-one C9H7BrO2;7-bromo-2,3-dihydrobenzopyran-4-one
• CAS NO: 18442-22-3
• Molecular Formula: C₉H₇BrO₂
• Molecular Weight: 227.05468
• EINECS: 1308068-626-2
• Product Categories: 18442-22-3
• Mol File: 18442-22-3.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 336.585 °C at 760 mmHg
• Flash Point: 157.361 °C
• Appearance: /
• Density: 1.622 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.599
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 7-Bromo-4-chromanone(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Bromo-4-chromanone(18442-22-3)
• EPA Substance Registry System: 7-Bromo-4-chromanone(18442-22-3)

Safety Data

• Hazardous Substances Data: 18442-22-3(Hazardous Substances Data)

Usage

Uses

Used as a?intermediate for??R & D.

Synthesis

7-Bromochroman-4-one was synthesized by hydrogenation addition of 7-Bromo-benzopyrone catalyzed by Wilkinson's catalyst Rhodium( Ⅰ) tris( triphenylphosphine) chloride[Rh( PPh3)3Cl]. The structure was confirmed by1 H NMR and MS. The optimum reaction conditions for synthesizing 7-Bromochroman-4-one were as follows: 5 0. 329 mol,ethanol as the solvent,c( 5) =0. 4 mol·L- 1,4% mol Rh( PPh3)3Cl as the catalyst,under 0. 3 MPa of hydrogen pressure,at 70℃ for 20 h,the yield was 79. 8%.

InChI:InChI=1/C9H7BrO2/c10-6-1-2-7-8(11)3-4-12-9(7)5-6/h1-2,5H,3-4H2

Upstream product

• 591-20-8 3-Bromophenol 
• 1016736-70-1 3-(3-bromophenoxy)propanenitrile 
• 288067-35-6 4-bromo-2-hydroxy-benzonitrile 
• 876149-55-2 C₁₁H₁₂BrNO₂ 
• 945724-02-7 (E)-1-(4-bromo-2-hydroxyphenyl)-3-(dimethylamino)prop-2-en-1-one 
• 30186-18-6 4'-bromo-2'-hydroxyacetophenone 
• 1493-13-6 trifluorormethanesulfonic acid 
• 18386-03-3 3-(3-bromophenoxy)propionic acid 
• 491-37-2 2,3-dihydro-4H-1-benzopyran-4-one 
• 168759-60-2 7-bromo-4H-benzopyran-4-one 
• 890840-78-5 C₉H₆BrClO 

Downstream Products

• 1180671-97-9 7-bromo-3-amino-chroman-4-one hydrochloride 
• 1180671-95-7 (E,Z)-7-bromochroman-4-one O-tosyl oxime 
• 1396777-41-5 8-bromo-3,4-dihydro-2H-benzo[f][1,4]oxazepin-5-one 

Relevant articles and documents

Acid activated montmorillonite K-10 mediated intramolecular acylation: Simple and convenient synthesis of 4-chromanones

3-Aryloxyproionic acids undergo intramolecular cyclization in the presence of AA.Mont.K-10 in toluene under reflux for 30–45 min in good to excellent yields. Phenyl ring bearing various substituents at the ortho, meta, para positions undergo this cyclization reaction. This method involves simple work up and amenable for large scale preparations. The heterogeneous acid treated catalyst can be regenerated and used for up to three cycles with minimum loss of activity.

CHROMANE-SUBSTITUED TETRACYCLIC COMPOUNDS AND USES THEREOF FOR TREATMENT OF VIRAL DISEASES

Disclosed are novel chromane-substituted tetracyclic compounds of Formula (I), and pharmaceutically acceptable salts thereof, wherein A, A', R2 R3, R4 and R5 are as defined in the description. Also disclosed are compositions comprising a chromane-substituted tetracyclic compound, and methods of using the chromane-substituted tetracyclic compounds for treating or preventing HCV infection in a patient.

ARYL SULFONAMIDES AS BLT1 ANTAGONISTS

Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are antagonists of leukotriene B4 receptor 1 (BLT1) and may be useful in the treatment, prevention and suppression of diseases mediated by the leu