184532-46-5Relevant academic research and scientific papers
Enantiodivergent synthesis of 2-hydroxymethyl-3-hydroxy-4-nitro-pyrrolidines through tandem Michael-Henry reaction using L-serine as the chiral educt
Barco, Achille,Benetti, Simonetta,De Risi, Carmela,Pollini, Gian P.,Romagnoli, Romeo,Zanirato, Vinicio
, p. 7599 - 7602 (2007/10/03)
By utilizing L-serine, both enantiomers of all trans 2-hydroxymethyl-3-hydroxy-4-nitro-pyrrolidine were efficiently prepared through tandem Michael-Henry methodology. Their stereochemistry has been assigned through conversions of one of them to trans 2-hydroxymethyl-3-hydroxypyrrolidine, a naturally occurring compound recently is isolated from Castanospermum australe.
