18455-64-6Relevant academic research and scientific papers
Intramolecular oxidative coupling: I2/TBHP/NaN3-mediated synthesis of benzofuran derivatives
Xu, Wengang,Li, Qingcui,Cao, Chuanpeng,Zhang, Fanglin,Zheng, Hua
supporting information, p. 6158 - 6161 (2015/06/08)
A novel intramolecular oxidative coupling reaction has been established to prepare benzofuran derivatives via direct C(sp2)-H functionalization for the formation of C-O bond. This transformation is mediated by I2/TBHP/NaN3 under metal-free conditions and a catalytic amount of NaN3 plays a crucial role in the reaction. Furthermore, the reaction tolerates a broad substrate scope with average to excellent yields.
An advanced and novel one-pot synthetic method for diverse benzo[c]chromen-6-ones by transition-metal free mild base-promoted domino reactions of substituted 2-hydroxychalcones with β-ketoesters and its application to polysubstituted terphenyls
Poudel, Tej Narayan,Lee, Yong Rok
, p. 919 - 930 (2014/02/14)
Novel and efficient one-pot syntheses of a variety of benzo[c]chromen-6-one derivatives were accomplished using Cs2CO3-promoted reactions between substituted 2-hydroxychalcones and β-ketoesters. These reactions involved domino Michael addition/intramolecular aldol/oxidative aromatization/lactonization and provided a rapid synthetic route for the production of biologically interesting novel benzo[c]chromen-6-one molecules bearing several different substituents on benzene rings. As an application of this methodology, several synthesized benzo[c]chromen-6-ones were transformed into highly functionalized novel terphenyls.
Certain pyrazoline derivatives with kinase inhibitory activity
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Page/Page column 91, (2008/12/06)
The present invention provides certain pyrazoline compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutical compositions and methods of using the compositions in the treatment of various diseases.
