184584-94-9

Upstream product

• 944154-72-7 9β-13-O-[(2R,3S)-3-(tert-butyloxycarbonylamino)-2-(triethylmethylsiloxy)-3-phenylpropionyl]-10-deacetyl-9-dihydro-9,10-O-(2-allylidene)-7-O-triethylsilylbaccatin III 
• 184586-03-6 9β-10-deacetyl-9-dihydro-9,10-O-(2-allylidene)-7-O-triethylsilylbaccatin III 
• 184586-22-9 9β-10-deacetyl-9-dihydro-9,10-O-(2-allylidene)baccatin III 
• 162475-68-5 10-deacetyl-9β-dihydrobaccatin III 
• 32981-86-5 10-deacetylbaccatin III 
• 184586-26-3 C₅₂H₇₁NO₁₄Si 

Downstream Products

• 944154-73-8 9β-13-O-[(2R,3S)-3-(tert-butyloxycarbonylamino)-2-hydroxyl-3-phenylpropionyl]-10-deacetyl-9-dihydro-9,10-O-(2,3-dihydroxylpropy)baccatin III 
• 944154-60-3 9β-13-O-[(2R,3S)-3-(tert-butyloxycarbonylamino)-2-hydroxyl-3-phenylpropionyl]-10-deacetyl-9-dihydro-9,10-O-[2-N-(2S,4S)-2-oxa-5-aza-bicyclo[2.2.1]hept-5-ylmethyl]baccatin III 
• 944154-58-9 9β-13-O-[(2R,3S)-3-(tert-butyloxycarbonylamino)-2-hydroxyl-3-phenylpropionyl]-10-deacetyl-9-dihydro-9,10-O-acetaldehydebaccatin III 

Relevant academic research and scientific papers

TAXOL DERIVATIVES WITH ANTITUMOR ACTIVITY

Taxol derivatives or their salts having the formula as following: Wherein, R1, R2, Z1, Z2, Z3 and Z4 are defined as the description. Their preparation methods and their use as antitumor agent are also disclosed.

New highly active taxoids from 9β-Dihydrobaccatin-9,10-acetals

To synthesize new highly active taxoids, we designed and synthesized 9β-dihydro-9,10-acetal taxoids. In vitro study of these analogues clearly showed them to be more potent than docetaxel.