162475-68-5

Upstream product

• 32981-86-5 10-deacetylbaccatin III 

Downstream Products

• 184586-22-9 9β-10-deacetyl-9-dihydro-9,10-O-(2-allylidene)baccatin III 
• 158976-88-6 10-deacetyl-7,10-bis TES-9β-dihydrobaccatin III 
• 184586-17-2 C₃₇H₄₄O₁₁ 
• 184759-17-9 C₃₂H₄₂O₁₀ 
• 184586-03-6 9β-10-deacetyl-9-dihydro-9,10-O-(2-allylidene)-7-O-triethylsilylbaccatin III 
• 184584-94-9 9β-13-O-[(2R,3S)-3-(tert-butyloxycarbonylamino)-2-hydroxyl-3-phenylpropionyl]-10-deacetyl-9-dihydro-9,10-O-(2-allylidene)baccatin III 
• 184586-26-3 C₅₂H₇₁NO₁₄Si 
• 184586-23-0 C₅₃H₇₅NO₁₅Si 
• 184586-16-1 C₅₃H₇₇NO₁₅Si 
• 184586-18-3 C₅₈H₇₉NO₁₆Si 
• 443096-28-4 C₆₂H₁₀₁NO₁₅Si₃ 

Relevant academic research and scientific papers

Stereoselective Synthesis of 9β-Hydroxytaxanes via Reduction with Samarium Diiodide

Reaction of baccatin III and paclitaxel with samarium diiodide yielded the corresponding 10-deacetyl-9β-hydroxy derivatives.When 10-deacetylbaccatin III and docetaxel were subjected to the same reaction conditions the corresponding 9β-hydroxy and 10-dehyd

Taxane Compounds, Compositions And Methods

The present invention provides a method for the preparation of orally available pentacyclic taxane compounds, as well as intermediates useful in their preparation.

TAXOL DERIVATIVES WITH ANTITUMOR ACTIVITY

Taxol derivatives or their salts having the formula as following: Wherein, R1, R2, Z1, Z2, Z3 and Z4 are defined as the description. Their preparation methods and their use as antitumor agent are also disclosed.

New highly active taxoids from 9β-Dihydrobaccatin-9,10-acetals

To synthesize new highly active taxoids, we designed and synthesized 9β-dihydro-9,10-acetal taxoids. In vitro study of these analogues clearly showed them to be more potent than docetaxel.

C2 substituted phenyl taxane derivatives and pharmaceutical compositions containing them

Taxane derivatives having alternative C2 substituents.

C13 amido substituted taxane derivatives and pharmaceutical compositions containing them

Taxane derivatives having an amino substituted C13 side chain.

The chemistry of the taxane diterpene: Stereoselective reductions of taxanes

Stereoselective reductions of taxanes are detailed. Chelation- controlled reductions employing SmI2 are described for the stereoselective reduction of the 9-keto functionality of the diterpene moiety of several taxanes. In all cases the 9β-hydr