184586-22-9

Upstream product

• 3054-95-3 acrylaldehyde diethyl acetal 
• 162475-68-5 10-deacetyl-9β-dihydrobaccatin III 
• 32981-86-5 10-deacetylbaccatin III 

Downstream Products

• 184586-26-3 C₅₂H₇₁NO₁₄Si 
• 184586-23-0 C₅₃H₇₅NO₁₅Si 
• 944154-58-9 9β-13-O-[(2R,3S)-3-(tert-butyloxycarbonylamino)-2-hydroxyl-3-phenylpropionyl]-10-deacetyl-9-dihydro-9,10-O-acetaldehydebaccatin III 
• 944154-73-8 9β-13-O-[(2R,3S)-3-(tert-butyloxycarbonylamino)-2-hydroxyl-3-phenylpropionyl]-10-deacetyl-9-dihydro-9,10-O-(2,3-dihydroxylpropy)baccatin III 
• 944154-60-3 9β-13-O-[(2R,3S)-3-(tert-butyloxycarbonylamino)-2-hydroxyl-3-phenylpropionyl]-10-deacetyl-9-dihydro-9,10-O-[2-N-(2S,4S)-2-oxa-5-aza-bicyclo[2.2.1]hept-5-ylmethyl]baccatin III 
• 184584-94-9 9β-13-O-[(2R,3S)-3-(tert-butyloxycarbonylamino)-2-hydroxyl-3-phenylpropionyl]-10-deacetyl-9-dihydro-9,10-O-(2-allylidene)baccatin III 
• 184586-03-6 9β-10-deacetyl-9-dihydro-9,10-O-(2-allylidene)-7-O-triethylsilylbaccatin III 

Relevant academic research and scientific papers

New highly active taxoids from 9β-Dihydrobaccatin-9,10-acetals

To synthesize new highly active taxoids, we designed and synthesized 9β-dihydro-9,10-acetal taxoids. In vitro study of these analogues clearly showed them to be more potent than docetaxel.

Taxane Compounds, Compositions And Methods

The present invention provides a method for the preparation of orally available pentacyclic taxane compounds, as well as intermediates useful in their preparation.

TAXOL DERIVATIVES WITH ANTITUMOR ACTIVITY

Taxol derivatives or their salts having the formula as following: Wherein, R1, R2, Z1, Z2, Z3 and Z4 are defined as the description. Their preparation methods and their use as antitumor agent are also disclosed.