184766-53-8

Upstream product

• 18093-12-4 3-chloro-4-methoxyphenol 
• 100-97-0 hexamethylenetetramine 

Downstream Products

• 184766-81-2 4-Chloro-2-(3-{1,1-dimethyl-2-[4-(4-methyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenylamino]-ethylamino}-2-hydroxy-propoxy)-5-(tetrahydro-pyran-2-yloxy)-benzonitrile 
• 184766-77-6 1-[5-chloro-2-cyano-4-(tetrahydropyran-2-yloxy)phenoxy]-2,3-epoxypropane 
• 184766-73-2 4-Chloro-2-hydroxy-5-(tetrahydro-pyran-2-yloxy)-benzonitrile 
• 184766-64-1 6-Chloro-benzo[d]isoxazol-5-ol 
• 184766-59-4 6-chloro-5-methoxybenzisoxazole 

Relevant academic research and scientific papers

BENZOFURAN AND BENZOTHIOPHENE-2-CARBOXYLIC ACID AMIDE DERIVATIVES

The present invention relates to compounds of formula I wherein X, A and R1 to R4 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.

Studies on agents with vasodilator and β-blocking activities. IV

A series of novel pyridazinone derivatives (II) having a phenoxypropanolamine moiety was synthesized. Their hypotensive and β- blocking activities were evaluated after intravenous administration of the compounds to anesthetized rats. Among them, the 5-chloro-2-cyanophenoxy derivative (29) showed the promising dual activities and was selected for further studies.