184779-15-5

Basic information

• Product Name: Ethanol, 2-[[6-chloro-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]oxy]-
• CAS NO: 184779-15-5
• Molecular Formula: C17H15ClN4O4
• Molecular Weight: 374.783
• Mol File: 184779-15-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Ethanol, 2-[[6-chloro-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]oxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanol, 2-[[6-chloro-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]oxy]-(184779-15-5)
• EPA Substance Registry System: Ethanol, 2-[[6-chloro-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]oxy]-(184779-15-5)

Safety Data

• Hazardous Substances Data: 184779-15-5(Hazardous Substances Data)

Upstream product

• 1177447-87-8 4-(2-tert-butoxyethoxy)-5-(2-methoxyphenoxy)-6-chloro-2,2'-bipyrimidine 
• 1160515-45-6 2-(5-(2-methoxy-phenoxy)-6-chloro-2-(pyrimidin-2-yl)pyrimidin-4-yloxy)ethanol formyl ether 
• 107-21-1 ethylene glycol 
• 150728-13-5 4,6-dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine 

Downstream Products

• 1160515-46-7 2-(5-(2-methoxy-phenoxy)-6-chloro-2-(pyrimidin-2-yl)pyrimidin-4-yloxy)ethanol acetyl ester 
• 147536-97-8 bosentan 

Relevant articles and documents

A PROCESS FOR THE PREPARATION OF BOSENTAN

The present invention relates to an improved process for the preparation of Bosentan or its salt. The present invention also relates to an improved process for the deprotection of hydroxy protected Bosentan. The present invention further relates to a pharmaceutical composition comprising Bosentan of formula I with excipients.

Process for the Preparation of Bosentan

A process for the preparation of 4-tert-butyl-N-[6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-[2,2′]bipyrimidinyl-4-yl]-benzenesulfonamide, bosentan, comprising the reaction of a compound of formula (II) or a salt thereof, wherein Z is an optionally protected hydroxy group, with a compound of formula (III), in the presence of a base; and, if necessary, the removal of the hydroxy-protecting group, and/or, if desired, the conversion of a compound of formula (I) to a salt thereof, or vice versa; and novel intermediates useful for its synthesis.

Sulfonamide derivative and process for preparing the same

Novel sulfonamide derivatives of the formula ?I!: STR1 wherein Ring A and Ring B are substituted or unsubstituted monocyclic, bicyclic or tricyclic hydrocarbon, or substituted or unsubstituted heterocyclic group, Q is single bond, --O--, --S--, --SO--, --