2-(5-(2-Methoxy-phenoxy)-6-chloro-2-(pyrimidin-2-yl)pyrimidin-4-yloxy)ethanol

Base Information

Chemical Name:2-(5-(2-Methoxy-phenoxy)-6-chloro-2-(pyrimidin-2-yl)pyrimidin-4-yloxy)ethanol
CAS No.:184779-15-5
Molecular Formula:C17H15ClN4O4
Molecular Weight:374.783
Hs Code.:
DSSTox Substance ID:DTXSID20596596
Wikidata:Q82491894
Mol file:184779-15-5.mol

Synonyms:184779-15-5;SCHEMBL1009078;DTXSID20596596;CCJDOHMWYKXBNA-UHFFFAOYSA-N;2-(5-(2-Methoxy-phenoxy)-6-chloro-2-(pyrimidin-2-yl)pyrimidin-4-yloxy)ethanol;DB-089559;2-{[6-Chloro-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]oxy}ethan-1-ol;2-{6-chloro-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)pyrimidin-4-yloxy}-ethanol

Suppliers and Price of 2-(5-(2-Methoxy-phenoxy)-6-chloro-2-(pyrimidin-2-yl)pyrimidin-4-yloxy)ethanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(5-(2-Methoxy-phenoxy)-6-chloro-2-(pyrimidin-2-yl)pyrimidin-4-yloxy)ethanol

Chemical Property:

XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:7
Exact Mass:374.0781827
Heavy Atom Count:26
Complexity:416

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=CC=C1OC2=C(N=C(N=C2Cl)C3=NC=CC=N3)OCCO

Technology Process of 2-(5-(2-Methoxy-phenoxy)-6-chloro-2-(pyrimidin-2-yl)pyrimidin-4-yloxy)ethanol

There total 4 articles about 2-(5-(2-Methoxy-phenoxy)-6-chloro-2-(pyrimidin-2-yl)pyrimidin-4-yloxy)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.7%

: 107-21-1
ethylene glycol

: 150728-13-5
4,6-dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine

: 184779-15-5
2-(5-(2-methoxy-phenoxy)-6-chloro-2-(pyrimidin-2-yl)pyrimidin-4-yloxy) ethanol

Guidance literature:: With triethylamine; at 100 ℃; for 3 - 4h; Product distribution / selectivity;

Reference yield:

: 1177447-87-8
4-(2-tert-butoxyethoxy)-5-(2-methoxyphenoxy)-6-chloro-2,2'-bipyrimidine

: 184779-15-5
2-(5-(2-methoxy-phenoxy)-6-chloro-2-(pyrimidin-2-yl)pyrimidin-4-yloxy) ethanol

Guidance literature:: 4-(2-tert-butoxyethoxy)-5-(2-methoxyphenoxy)-6-chloro-2,2'-bipyrimidine; With hydrogenchloride; isopropyl alcohol; In ethanol; at 60 - 65 ℃;

With ammonia; In water; pH=7;

Reference yield:

: 1160515-45-6
2-(5-(2-methoxy-phenoxy)-6-chloro-2-(pyrimidin-2-yl)pyrimidin-4-yloxy)ethanol formyl ether

: 184779-15-5
2-(5-(2-methoxy-phenoxy)-6-chloro-2-(pyrimidin-2-yl)pyrimidin-4-yloxy) ethanol

Guidance literature:: 2-(5-(2-methoxy-phenoxy)-6-chloro-2-(pyrimidin-2-yl)pyrimidin-4-yloxy)ethanol formyl ether; With water; sodium hydroxide; In ethanol; at 25 - 30 ℃; for 1h;

With hydrogenchloride; water; In water; at 10 - 15 ℃; pH=4 - 5;