18480-52-9Relevant articles and documents
Preparation method of 3,4- dichloro5-cyanisothiazole
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Paragraph 0026; 0027; 0032; 0033, (2019/02/25)
The invention provides a preparation method of 3,4- dichloro5-cyanisothiazole. Low-toxicity iron and cyanogen compounds are used as initial raw materials to react with carbon dioxide and chlorine gasunder the catalysis effect of catalysts; the purity of an obtained product can reach 98 percent. The use of highly toxic sodium cyanide is avoided; the industrial production safety is improved; raw materials are conventional compounds; the price is low; the process is simple and is suitable for amplified production.
Method of manufacturing benzisothiazol compd.
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Paragraph 0123; 0130, (2016/10/08)
[Problem to be Solved] To provide an industrially preferred process for producing an isothiazole compound, particularly 3,4-dichloro-5-cyanoisothiazole. For example, to provide a safer industrial production process by avoiding the simultaneous use of an aprotic polar solvent such as N,N-dimethylformamide and chlorine. In addition, to provide a production process which is economically preferred because an aprotic polar solvent, which is highly likely to become a part of waste, is not used. [Solution] A process for producing an isothiazole compound represented by a general formula (3), wherein R is a cyano group or the like; and X is a chlorine atom or the like, which comprises heating a nitrile compound represented by a general formula (1), wherein R is as defined above, and sulfur, and then carrying out a reaction between the nitrile compound represented by the general formula (1), the sulfur and a halogen represented by a general formula (2), wherein X is as defined above.
PROCESS FOR PRODUCING ISOTHIAZOLE DERIVATIVE
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Page/Page column 6, (2012/03/10)
A process for producing 3,4-dichloro-5-cyanoisothiazole represented by a general formula (3): the process comprising: reacting a nitrile compound represented by a general formula (1): (wherein “n” denotes an integer of 0 to 2), with sulfur chloride represented by a general formula (2): [Chemical Formula 18] SmCl2 ??(2) (wherein “m” represents an integer of 1 to 2), or a mixture thereof in an aprotic polar solvent. There is provided a process for producing 3,4-dichloro-5-cyanoisothiazole, which is capable of suppressing by-production of a waste, without using a raw material having a having a strong toxicity; and is capable of providing a product having a higher purity in a high yield and efficiency in an industrial scale, in a simple manner.