184835-94-7Relevant articles and documents
Visible-light-promoted photocatalyst-free alkylation and acylation of benzothiazoles
Jiang, Pengxing,Liu, Li,Tan, Jiajing,Du, Hongguang
supporting information, p. 4487 - 4491 (2021/05/31)
Herein we report a protocol for the visible-light-mediated alkylation/acylation reaction of benzothiazoles. Alkyl/acyl substituted Hantzsch esters are easily prepared and rationally used as radical precursors. In the presence of BF3·Et2O and Na2S2O8, various benzothiazole derivatives were readily obtained in good yields. Our user-friendly protocol can proceed by simple irradiation with blue LEDs (λ = 465 nm) and without the assistance of external photocatalysts. The reaction is also characterized by mild conditions and scalability, thus offering an alternative and efficient tool for the synthesis of 2-functionalized benzothiazoles.
Visible-light induced decarboxylative C2-alkylation of benzothiazoles with carboxylic acids under metal-free conditions
Wang, Bin,Li, Pinhua,Miao, Tao,Zou, Long,Wang, Lei
, p. 115 - 121 (2019/01/04)
An effective protocol of photoredox catalyzed C2-alkylation of benzothiazoles with aliphatic carboxylic acids was disclosed. In the presence of an acridinium salt as a photocatalyst and air as an oxidant, a wide range of secondary or tertiary aliphatic ca
External Oxidant-Free Oxidative Cross-Coupling: A Photoredox Cobalt-Catalyzed Aromatic C-H Thiolation for Constructing C-S Bonds
Zhang, Guoting,Liu, Chao,Yi, Hong,Meng, Qingyuan,Bian, Changliang,Chen, Hong,Jian, Jing-Xin,Wu, Li-Zhu,Lei, Aiwen
supporting information, p. 9273 - 9280 (2015/08/11)
An external oxidant-free oxidative coupling for aromatic C-H thiolation by visible-light photoredox cobalt-catalysis has been developed. Various substrates could afford benzothiazoles in good to excellent yields, and only H2 is generated as a side product. When catalytic TBAOH was used as the base, not only 2-aryl but also 2-alkylbenzothiazoles could be obtained through this novel dehydrogenative coupling reaction. This method could be scaled up and applied to the synthesis of biologically active molecules bearing benzothiazole structural scaffolds (potent antitumor agents). Furthermore, the unexpected oxidation byproduct amides, which are often generated in oxidative cyclization of thiobenzanilides, can be completely avoided. Mechanistic studies showed that the H2 originates from the substrates. The kinetic studies indicate that the interaction between the cobalt catalyst and proton might be involved in the rate-limiting process. (Chemical Equation Presented).