56619-94-4

Basic information

• Product Name: N-(4-Methoxyphenyl)pivalamide
• Synonyms: N-(4-Methoxyphenyl)-2,2-dimethylpropanamide;N-(4-Methoxyphenyl)pivalamide;2,2-DIMETHYL-4'-METHOXYPROPIONANILIDE
• CAS NO: 56619-94-4
• Molecular Formula: C₁₂H₁₇NO₂
• Molecular Weight: 207.27
• Mol File: 56619-94-4.mol
• Article Data: 23

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(4-Methoxyphenyl)pivalamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-Methoxyphenyl)pivalamide(56619-94-4)
• EPA Substance Registry System: N-(4-Methoxyphenyl)pivalamide(56619-94-4)

Safety Data

• Hazardous Substances Data: 56619-94-4(Hazardous Substances Data)

Upstream product

• 24331-71-3 N,N-dimethylpivalamide 
• 104-94-9 4-methoxy-aniline 
• 4920-92-7 pivalic acid phenyl ester 
• 75-84-3 2,2-dimethyl-propanol-1 
• 630-19-3 pivalaldehyde 
• 75-98-9 Trimethylacetic acid 
• 754-10-9 2,2-dimethylpropionamide 
• 623-12-1 4-chloromethoxybenzene 
• 15686-71-2 cefalexin 
• 51-66-1 4-methoxyacetanilide 
• 1227-44-7 N,N'-bis(4-methoxyphenyl)urea 
• 18437-68-8 tert-butyl N-(4-methoxyphenyl)carbamate 
• 1538-75-6 2,2-dimethylpropanoic anhydride 
• 3282-30-2 pivaloyl chloride 

Downstream Products

• 1190954-82-5 2-(2,2-dimethylpropionylamino)-5-methoxy-benzenesulfonic acid 
• 1190954-83-6 2-(2,2-dimethylpropionylamino)-5-hydroxy-benzenesulfonic acid 
• 2835-05-4 2-amino-5-hydroxy-benzenesulfonic acid 
• 13244-33-2 2-amino-5-methoxybenzenesulfonic acid 
• 1433186-65-2 N-(4-methoxy-2-(trifluoromethyl)phenyl)pivalamide 
• 54394-84-2 4'-(Methoxy)-thiopivalanilid 
• 184835-94-7 2-(tert-butyl)-6-methoxybenzo[d]thiazole 
• 1006-94-6 5-methoxylindole 

Relevant articles and documents

Ligand Promoted Olefination of Anilides for Indirectly Introducing Fluorinated Functional Groups via Palladium Catalyst

We report a palladium-catalyzed, ligand promoted, C-H fluorine-containing olefination of anilides with 4-bromo-3,3,4,4-tetrafluorobutene as the fluorinated reagent, which has a potential transformation into other compounds due to its -CF2CF2Br functional group. -CF2CF2H was obtained by using the mild reducing agent sodium borohydride. Bioactive compounds such as aminoglutethimide derivative and propham were well-tolerated in this reaction, both of which highlight the synthetic importance of this method.

General rhodium-catalyzed oxidative cross-coupling reactions between anilines: Synthesis of unsymmetrical 2,2′-diaminobiaryls

Described herein is a dual chelation-assisted RhCl3-catalyzed oxidative C-H/C-H cross-coupling reaction of aniline derivatives. The highlight of this methodology is the chemo- and regioselective cross-coupling between electronically similar substrates, which represents a highly challenging task in oxidative Ar-H/Ar-H cross-coupling reactions. Furthermore, this Cp?-free catalytic reaction tolerates a range of functional groups and requires only a low molar ratio of coupling partners. These features expedite the synthesis of unsymmetrical 2,2′-diaminobiaryls.

Rapidly Activating Pd-Precatalyst for Suzuki-Miyaura and Buchwald-Hartwig Couplings of Aryl Esters

Esters are valuable electrophiles for cross-coupling due to their ubiquity and ease of synthesis. However, harsh conditions are traditionally required for the effective cross-coupling of ester substrates. Utilizing a recently discovered precatalyst, Pd-catalyzed Suzuki-Miyaura and Buchwald-Hartwig reactions involving cleavage of the C(acyl)-O bond of aryl esters that proceed under mild conditions are reported. The Pd(II) precatalyst is highly active because it is reduced to the Pd(0) active species more rapidly than previous precatalysts.