184866-29-3

Basic information

• Product Name: (S)-Lercanidipine Hydrochloride
• Synonyms: (4S)-1,4-Dihydro-2,6-dimethyl-4-(3-nittrophenyl)-3,5-pyridinedicarboxylic Acid 2-[(3,3-Diphenylpropyl)methylamino]-1,1-dimethylethyl Methyl Ester Hydrochloride
• CAS NO: 184866-29-3
• Molecular Formula: C36H42ClN3O6
• Molecular Weight: 648.2
• Product Categories: Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Dihydropyridine
• Mol File: 184866-29-3.mol
• Article Data: 7

Chemical Properties

• Melting Point: 116-122°C
• Boiling Point: 712.5°C at 760 mmHg
• Flash Point: 384.7°C
• Appearance: /
• Vapor Pressure: 3.77E-20mmHg at 25°C
• Storage Temp.: -20°C Freezer
• CAS DataBase Reference: (S)-Lercanidipine Hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-Lercanidipine Hydrochloride(184866-29-3)
• EPA Substance Registry System: (S)-Lercanidipine Hydrochloride(184866-29-3)

Safety Data

• Hazardous Substances Data: 184866-29-3(Hazardous Substances Data)

Usage

Chemical Properties

Pale-Yellow Solid

Uses

A dihydropyridine calcium channel blocker

InChI:InChI=1/C36H41N3O6.ClH/c1-24-31(34(40)44-6)33(28-18-13-19-29(22-28)39(42)43)32(25(2)37-24)35(41)45-36(3,4)23-38(5)21-20-30(26-14-9-7-10-15-26)27-16-11-8-12-17-27;/h7-19,22,30,33,37H,20-21,23H2,1-6H3;1H/t33-;/m0./s1

Upstream product

• 100442-33-9 2,N-dimethyl-N-(3,3-diphenylpropyl)-1-amino-2-propanol 
• 99-61-6 3-nitro-benzaldehyde 
• 100427-51-8 1,1,N-trimethyl-N-(3,3-diphenylpropy)-2-aminoethyl acetoacetate 
• 929212-20-4 2-[(3-nitrophenyl)methylene]-3-oxobutanoic acid 2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethyl ethyl ester hydrochloride 
• 14205-39-1 methyl 3-aminocrotonate 
• 890045-70-2 1-chloro-2-methyl-2-propyl methyl 1 ,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-1-pyridine-3 ,5-dicarboxylate 
• 28075-29-8 N-methyl-3,3-diphenylpropylamine 
• 100427-26-7 lercanidipine 
• 21731-17-9 methyl 3-aminocrotonate 
• 957215-03-1 (R,S) 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl methyl ester oxalate 
• 88712-56-5 1,4-dihydro-2,6-dimethyl-3-methoxycarbonyl-4-(3-nitrophenyl)-pyridine-5-carboxylic acid chloride 

Relevant articles and documents

NOVEL PROCESS FOR THE PREPARATION OF LERCANIDIPINE

The invention provides a novel process for the preparation of lercanidipine or a pharmaceutical acceptable salt using novel intermediates. Thus, 2,N-dimethyl-N-(3,3-diphenylpropyl)-1-amino-2-propanol is reacted with trimethylsilyl chloride in presence of

PROCESS FOR PREPARING LERCANIDIPINE HYDROCHLORIDE

Disclosed herein is a novel method for preparing lercanidipine hydrochloride which is highly effective for treating hypertension. The method comprises the steps of reacting 2,6-dimethyl-5-methoxycarbonyl-4-(3- nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid with a substituted chlorophosphate derivative to obtain a substituted phosphonoester derivative, and reacting the substituted phosphonoester derivative with 2, N-dimethyl-N- (3,3-diphenylpropyl)-1-amino-2-propanol. According to the preparation method, since little by-products are formed, the yield is improved, as compared to cases of conventional methods. In addition, the method involves simple isolation and purification processes of lercanidipine, thus realizing a high-quality product. Furthermore, the method has advantages of low preparation costs, substantial waste-free environmental-friendly process and applicability to industrial mass-production.

Process for Producing Lercanidipine

A process for preparing 1,4-dihydro-2,6-dimethyl-4- (3-nitrophenyl) -3,5-pyridinedicarboxylic acid 2- [(3,3-diphenyl-propyl) methylamino]-1,1-dimethylethyl ester (Lercanidipine) I, which comprises reacting 1,4-dihydro-2,6-dimethyl-4- (3-nitrophenyl) -3,5-