184882-04-0

Basic information

• Product Name: Benzenemethanol, 5-chloro-2-[(2,2-dimethylpropyl)amino]-a-phenyl-
• CAS NO: 184882-04-0
• Molecular Formula: C18H22ClNO
• Molecular Weight: 303.832
• Mol File: 184882-04-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzenemethanol, 5-chloro-2-[(2,2-dimethylpropyl)amino]-a-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, 5-chloro-2-[(2,2-dimethylpropyl)amino]-a-phenyl-(184882-04-0)
• EPA Substance Registry System: Benzenemethanol, 5-chloro-2-[(2,2-dimethylpropyl)amino]-a-phenyl-(184882-04-0)

Safety Data

• Hazardous Substances Data: 184882-04-0(Hazardous Substances Data)

Upstream product

• 630-19-3 pivalaldehyde 
• 1159372-20-9 (2-amino-5-chlorophenyl)(phenyl)methanol 
• 719-59-5 5-chloro-2-aminobenzophenone 

Downstream Products

• 406684-70-6 (E)-3-[[4-Chloro-2-(hydroxy-phenyl-methyl)-phenyl]-(2,2-dimethyl-propyl)-carbamoyl]-acrylic acid ethyl ester 

Relevant articles and documents

Discovery of a new 2-aminobenzhydrol template for highly potent squalene synthase inhibitors

To obtain small and efficient squalene synthase inhibitors, a flexible 2-aminobenzhydrol open form structure was designed and showed potent inhibitory activity comparable to 4,1-benzoxazepin compounds. Further chemical modification led to the discovery of a novel template with a strong squalene synthase inhibitory activity, and its basic structure-activity relationship was revealed. The X-ray crystallographic data of compound 12 bound to the active site of squalene synthase provided an important insight into the binding mode of this alternative template that formed 11-membered ring conformations with an intramolecular hydrogen bond.