1849-71-4

Usage

Chemical Properties

White solid

InChI:InChI=1/C7H4Cl2N2S/c8-3-1-2-4-6(5(3)9)11-7(10)12-4/h1-2H,(H2,10,11)

Upstream product

• 41542-06-7 1-(2,3-dichlorophenyl)thiourea 
• 333-20-0 potassium thioacyanate 
• 608-27-5 2,3-dichloroaniline 

Downstream Products

• 1267448-26-9 6,7-dichloro-4-phenyl-2H-pyrimido[2,1-b]benzothiazol-2-one 
• 1422007-16-6 3-(4′,5′-dichlorobenzothiazol-2-yl)-2-(4′-chlorostyryl)quinazolin-4(3H)-one 
• 1422007-12-2 3-(4′,5′-dichlorobenzothiazol-2-yl)-2-(4′-methoxystyryl)quinazolin-4(3H)-one 
• 126764-57-6 2-amino-3,4-dichlorobenzenethiol 
• 1849-69-0 2-Brom-4,5-dichlor-benzothiazol 

Relevant academic research and scientific papers

A novel system for the synthesis of 2-aminobenzthiazoles using sodium dichloroiodate

2-Aminobenzthiazole is a privileged scaffold with a range of biological activities. However, to date, an efficient protocol for the synthesis of this ring system using aniline as a starting material has been lacking. Herein, for the first time, we describe a highly efficient and mild protocol for the synthesis of 2-aminiobenzthiazole using NaICl Georg Thieme Verlag Stuttgart ? New York.

Synthesis and antimicrobial activity of 2H-pyrimido[2,1-b]benzothiazol-2- ones

4-Phenyl-2H-pyrimido[2,1-b]benzothiazol-2-ones have been synthesized in quantitative yields by the reaction of 2-aminobenzothiazoles with alkynoic acid. The antimicrobial activity of the synthesized compounds was tested against bacterial species, Bacillus coagulans, Bacillus subtilis, Staphylococcus aureus, and Pseudomonas aeruginosa. The synthesized compounds have shown significant activity against microorganisms which can be correlated with the fused heterocyclic systems.

Ion channel modulating agents

The present invention relates to ion channel modulating agents. More particularly, the present invention relates to a particular class of chemical compounds represented by general formula (I) that has proven useful as modulators of SKCa, IKCa and BKCa channels. In further aspects, the present invention relates to the use of these SK/IK/BK channel modulating agents for the manufacture of medicaments, and pharmaceutical compositions comprising the SK/IK/BK channel modulating agents. The SK/IK/BK channel modulating agents of the invention are useful for the treatment or alleviation of diseases and conditions associated with the SK/IK/BK channels.