1849-86-1

Usage

Uses

Used in Pharmaceutical Research:
1-(1,3-benzothiazol-2-yl)-3-phenylthiourea is used as a research compound for its potential anti-cancer properties. Its unique structure allows it to be a versatile building block in the development of new drugs targeting various types of cancer.
Used in Organic Synthesis:
1-(1,3-benzothiazol-2-yl)-3-phenylthiourea is used as a synthetic building block for the creation of various organic molecules. Its reactivity and unique structure make it a valuable component in the synthesis of complex organic compounds.
Used in Antimicrobial Applications:
1-(1,3-benzothiazol-2-yl)-3-phenylthiourea is used as an antimicrobial agent due to its potential to combat various types of bacteria and other microorganisms. Its effectiveness in this application is currently under investigation.
Used in Anti-inflammatory Applications:
1-(1,3-benzothiazol-2-yl)-3-phenylthiourea is used as an anti-inflammatory agent, potentially providing relief from inflammation and associated pain. Further research is needed to fully understand its potential in this area.

Upstream product

• 136-95-8 2-amino-benzthiazole 
• 103-72-0 phenyl isothiocyanate 
• 67344-86-9 1,5-diphenyl-2-(S-benzyl)-2,4-isodithiobiuret 
• 21985-04-6 3-phenyl-1-(2-thienyl)-2-propyn-1-one 
• 57633-33-7 N-phenyl-3-phenylimino-3H-1,2,4-dithiazol-5-amine 
• 7338-94-5 1,3-diphenyl-2-propynone 
• 1817-57-8 4-phenyl-3-butyne-2-one 

Downstream Products

• 109512-58-5 benzothiazol-2-yl-phenyl-carbodiimide 
• 77007-12-6 N-benzothiazol-2-yl-N'-phenyl-guanidine 
• 26135-12-6 1-(benzo[d]thiazol-2-yl)-3-phenylurea 
• 170952-00-8 N-phenyl-N',N''-bis(benzothiazol-2-yl)guanidine 
• 79245-53-7 UO₂(C₇H₄NSNHC(S)NC₆H₅)2 
• 79245-58-2 VO(C₇H₄NSNHC(S)NC₆H₅)2 
• 79245-54-8 Cd(C₇H₄NSNHC(S)NC₆H₅)2(H₂O)2 
• 79245-57-1 Mn(C₇H₄NSNHC(S)NC₆H₅)2(H₂O)2 
• 79245-55-9 Zn(C₇H₄NSNHC(S)NC₆H₅)2(H₂O)2 
• 79245-56-0 Fe(C₇H₄NSNHC(S)NC₆H₅)2(H₂O)2 

Relevant academic research and scientific papers

Synthetic access to some new benzothiazole-based 1,3,4-thiadiazole and 1,3-thiazole derivatives

1-(Benzothiazol-2-yl)-3-phenylthiourea 2 was prepared and treated with hydrazonoyl chlorides 3a-e to yield the corresponding 5-(benzothiazol-2-ylimino)-1,3,4-thiadiazole derivatives 6a-e, respectively. Reaction of the thiourea derivative 2 with ethyl 2-ch

Quantum, characterization and spectroscopic studies on Cu(II), Pd(II) and Pt(II) complexes of 1-(benzo[d]thiazol-2-yl)-3-phenylthiourea and its biological application as antimicrobial and antioxidant

Divalent platinum, palladium and copper chelates of H2PhT have been isolated and identified. Their structures have been elucidated by partial elemental analyses, magnetic susceptibilities and spectroscopic estimations and additionally mass spec

Blue-light induced CO releasing properties of thiourea based manganese(I) carbonyl complexes

A new class of blue-light triggered carbon monoxide releasing molecules based on Mn(CO)3Br(N,S) ((N,S)?=?N,S-bidentate thiourea ligands) has been reported in this work. The 1H and 13C NMR analysis indicated that the thioureas coordinate to Mn(I) in the thione form. The stability test and the ability to derive CO to DMSO and myoglobin solution upon the exposure to 468?nm light source have been investigated. The benzothiazole-thiourea-CORM released only one CO equivalent, while the pyridine-analogs offered two molecules at the same experimental conditions. Natural bond orbital analysis has been carried out to give details about the hybridization of Mn–C and C[tbnd]O bonds, natural charge, electronic arrangement of metal ion and strength of interaction between Mn(I) and the coordination sites. Both functional, B3LYP and CAM-B3LYP compare well with the experimental findings, where the longest wavelength band is assigned to MLCT.

Synthesis and cytotoxic evaluation of thiourea and N-bis-benzothiazole derivatives: A novel class of cytotoxic agents

Benzothiazolyl thiocarbamides has been achieved using a catalytic amount of 4-dimethylaminopyridine (DMAP) followed by its chemoselective oxidative cyclization with 1,3-di-n-butylimidazolium tribromide[bbim][Br3] to afford the N-bis-benzothiazole derivatives. All the synthesized compounds were evaluated for cytotoxic activity against two human monocytic cell lines (U 937, THP-1) and a mouse melanoma cell line (B16-F10). Based on their IC50 values, the majority of the benzothiazolyl thiocarbamides and N-bis-benzothiazoles had significant antiproliferative activity on U 937 and B16-F10 cells, the compounds 3b, 3e, 3f, 3k, 6c and 6h were found to be the most active. The present findings indicate clearly that the compound 3e exhibited more antiproliferative activity on U 937 cells than the standard molecule, etoposide. Nevertheless, these compounds have shown comparatively less cytotoxicity towards THP-1 cells.

1,3-Di-n-butylimidazolium tribromide-mediated chemoselective oxidative cyclization of benzothiazoyl carbaimides: A novel approach toward the synthesis of N-bis-benzothiazole derivatives

4-(N,N-Dimethylamino)pyridine is found to be an efficient catalyst for the synthesis of benzothiazoyl carbaimide derivatives using 2-aminobenzothiazoles and phenylisothiocyanates, which on treatment with ionic liquid [bbim][Br 3] at 70°C afforded exclusive formation of N-bis-benzothiazole derivatives in good yield. Copyright

1,3-Dipolar cycloaddition of 3-phenylamino-5-phenylimino-1,2,4-dithiazole to 1-acyl-2-phenylacetylenes - A new route to functionalized 1,3-thiazole derivatives

3-Phenylamino-5-phenylimino-1,2,4-dithiazole reacted with 1-acyl-2-phenylacetylenes in ethanol or toluene on heating (78-80°C, 1 h) in chemo- and regioselective fashion to give previously unknown N-[5-acyl-3,4-diphenyl-1,3-thiazol-2(3H)-ylidene]-N′-phenyl