184906-31-8

Basic information

• Product Name: 2,3-dihydro-5-hydroxy-3,3-diMethyl-1H-Isoindol-1-one
• Synonyms: 2,3-dihydro-5-hydroxy-3,3-diMethyl-1H-Isoindol-1-one;5-hydroxy-3,3-diMethylisoindolin-1-one
• CAS NO: 184906-31-8
• Molecular Formula: C₁₀H₁₁NO₂
• Molecular Weight: 177.19984
• Mol File: 184906-31-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,3-dihydro-5-hydroxy-3,3-diMethyl-1H-Isoindol-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-dihydro-5-hydroxy-3,3-diMethyl-1H-Isoindol-1-one(184906-31-8)
• EPA Substance Registry System: 2,3-dihydro-5-hydroxy-3,3-diMethyl-1H-Isoindol-1-one(184906-31-8)

Safety Data

• Hazardous Substances Data: 184906-31-8(Hazardous Substances Data)

Usage

General Description

2,3-dihydro-5-hydroxy-3,3-diMethyl-1H-Isoindol-1-one, also known as leucomalachite green, is a chemical compound that is commonly used as a dye in the textile industry. It is a white to off-white solid with a molecular formula of C11H13NO2 and a molecular weight of 191.23 g/mol. Leucomalachite green is known for its ability to react with oxygen to form the dye malachite green, which is used as a biological stain and in the aquaculture industry as an antifungal agent. However, leucomalachite green is also a known carcinogen and has been banned in many countries due to its potential health risks. It is important to handle this chemical with caution and adhere to safety guidelines when working with it.

Upstream product

• 109138-26-3 1-(1-Isocyanato-1-methylethyl)-3-methoxybenzene 
• 17653-93-9 2-(3'-Methoxyphenyl)-2-methylpropionitrile 
• 17653-94-0 α-methyl-α-(3-methoxyphenyl)proprionic acid 
• 184906-29-4 5-methoxy-3,3-dimethylisoindolin-1-one 

Downstream Products

• 184906-32-9 3,3-Dimethyl-5-(1-phenyl-1H-tetrazol-5-yloxy)-2,3dihydroisoindol-1-one 
• 19194-52-6 3,3-dimethylisoindolin-1-one 
• 1033809-27-6 5-(2-chloro-4-nitrophenoxy)-3,3-dimethylisoindolin-1-one 

Relevant articles and documents

FUSED HETEROCYCLIC COMPOUND

The present invention provides a fused heterocyclic compound having a tyrosine kinase inhibitory action, which is represented by the formula: wherein R1 is a hydrogen atom, a halogen atom, or an optionally substituted group bonded via a carbon atom, a nitrogen atom or an oxygen atom; R2 is a hydrogen atom, or an optionally substituted group bonded via a carbon atom or a sulfur atom, or R1 and R2, or R2 and R3 are optionally bonded to each other to form an optionally substituted ring structure; R3 is a hydrogen atom or an optionally substituted aliphatic hydrocarbon group, or R3 is optionally bonded to the carbon atom on ring A to form an optionally substituted ring structure; ring A is an optionally substituted benzene ring; and ring B is (i) an optionally substituted fused ring, or (ii) a pyridine ring having optionally substituted carbamoyl (the pyridine ring is optionally further substituted).

Design, synthesis, and in vitro evaluation of cyclic nitrones as free radical traps for the treatment of stroke

Analogs of the cyclic nitrone free radical trap 1 (3,3-dimethyl-3,4- dihydroisoquinoline N-oxide, a cyclic analog of phenyl-tert-butylnitrone (PBN)) were prepared in which (1) the fused phenyl ring was replaced with a naphthalene ring, an electron rich heterocycle, or a dimethylphenol, (2) the nitrone-containing ring comprised five, six, or seven atoms, and (3) the gem- dimethyl group was replaced with spirocyclic groups. The most active antioxidant, which bears a dimethylphenol fused to a 7-membered ring nitrone (compound 6h), inhibited lipid peroxidation in vitro with an IC50 of 22 μM, a 75-fold improvement over that of 1. The previously observed correlation between lipophilicity and activity vs lipid peroxidation in vitro has been further substantiated and refined by this study. Moreover, certain classes of compounds (namely, dimethylphenols 6g, h and furan 6j) have now been found which are considerably more active in vitro than expected on the basis of their log k'(w) values.