184906-31-8

Usage

Uses

Used in Textile Industry:
2,3-dihydro-5-hydroxy-3,3-diMethyl-1H-Isoindol-1-one is used as a dye in the textile industry for its ability to produce vibrant colors on fabrics. Its colorfast properties make it a popular choice for various applications in this industry.
Used in Biological Staining:
Leucomalachite green is used as a biological stain due to its ability to form malachite green upon reaction with oxygen. Malachite green is used for staining biological specimens, making it easier to observe and study under a microscope.
Used in Aquaculture Industry:
In the aquaculture industry, leucomalachite green is used as an antifungal agent to prevent fungal infections in fish and other aquatic organisms. Its antifungal properties help maintain a healthy environment for aquatic life.
However, it is important to note that leucomalachite green is a known carcinogen and has been banned in many countries due to its potential health risks. It is crucial to handle this chemical with caution and adhere to safety guidelines when working with it.

Upstream product

• 109138-26-3 1-(1-Isocyanato-1-methylethyl)-3-methoxybenzene 
• 184906-29-4 5-methoxy-3,3-dimethylisoindolin-1-one 
• 17653-93-9 2-(3'-Methoxyphenyl)-2-methylpropionitrile 
• 17653-94-0 α-methyl-α-(3-methoxyphenyl)proprionic acid 

Downstream Products

• 184906-32-9 3,3-Dimethyl-5-(1-phenyl-1H-tetrazol-5-yloxy)-2,3dihydroisoindol-1-one 
• 19194-52-6 3,3-dimethylisoindolin-1-one 
• 1033809-27-6 5-(2-chloro-4-nitrophenoxy)-3,3-dimethylisoindolin-1-one 

Relevant academic research and scientific papers

FUSED HETEROCYCLIC COMPOUND

The present invention provides a fused heterocyclic compound having a tyrosine kinase inhibitory action, which is represented by the formula: wherein R1 is a hydrogen atom, a halogen atom, or an optionally substituted group bonded via a carbon atom, a nitrogen atom or an oxygen atom; R2 is a hydrogen atom, or an optionally substituted group bonded via a carbon atom or a sulfur atom, or R1 and R2, or R2 and R3 are optionally bonded to each other to form an optionally substituted ring structure; R3 is a hydrogen atom or an optionally substituted aliphatic hydrocarbon group, or R3 is optionally bonded to the carbon atom on ring A to form an optionally substituted ring structure; ring A is an optionally substituted benzene ring; and ring B is (i) an optionally substituted fused ring, or (ii) a pyridine ring having optionally substituted carbamoyl (the pyridine ring is optionally further substituted).

Cyclic nitrones

The present invention is directed to novel cyclic nitrones and their use in the prevention of oxidation tissue damage by free radicals, their use in the treatment of a number of disease states in which radicals either damage or destroy tissues via oxidation, and pharmaceutical compositions containing these cyclic nitrones.

Design, synthesis, and in vitro evaluation of cyclic nitrones as free radical traps for the treatment of stroke

Analogs of the cyclic nitrone free radical trap 1 (3,3-dimethyl-3,4- dihydroisoquinoline N-oxide, a cyclic analog of phenyl-tert-butylnitrone (PBN)) were prepared in which (1) the fused phenyl ring was replaced with a naphthalene ring, an electron rich heterocycle, or a dimethylphenol, (2) the nitrone-containing ring comprised five, six, or seven atoms, and (3) the gem- dimethyl group was replaced with spirocyclic groups. The most active antioxidant, which bears a dimethylphenol fused to a 7-membered ring nitrone (compound 6h), inhibited lipid peroxidation in vitro with an IC50 of 22 μM, a 75-fold improvement over that of 1. The previously observed correlation between lipophilicity and activity vs lipid peroxidation in vitro has been further substantiated and refined by this study. Moreover, certain classes of compounds (namely, dimethylphenols 6g, h and furan 6j) have now been found which are considerably more active in vitro than expected on the basis of their log k'(w) values.