18494-67-2

Basic information

• Product Name: 4-Heptanoylmorpholine
• Synonyms: 4-Heptanoylmorpholine;AI-3-35669aGa
• CAS NO: 18494-67-2
• Molecular Formula: C₁₁H₂₁NO₂
• Molecular Weight: 0
• Mol File: 18494-67-2.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 328°C at 760 mmHg
• Flash Point: 152.2°C
• Appearance: /
• Density: 0.984g/cm³
• Vapor Pressure: 0.000195mmHg at 25°C
• Refractive Index: 1.465
• CAS DataBase Reference: 4-Heptanoylmorpholine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Heptanoylmorpholine(18494-67-2)
• EPA Substance Registry System: 4-Heptanoylmorpholine(18494-67-2)

Safety Data

• Hazardous Substances Data: 18494-67-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H21NO2/c1-2-3-4-5-6-11(13)12-7-9-14-10-8-12/h2-10H2,1H3

Upstream product

• 23328-69-0 4-chloromorpholine 
• 111-71-7 heptanal 
• 110-91-8 morpholine 
• 1340546-37-3 1-heptanoyl-1,2-hydrazinedicarboxylic acid 1,2-diisopropyl ester 
• 111-14-8 oenanthic acid 
• 111-70-6 n-heptan1ol 
• 26256-86-0 C₁₃H₂₃NO 
• 17077-46-2 4-(3-phenyl-propionyl)-morpholine 
• 1002752-21-7 C₁₅H₂₃NO 
• 63833-44-3 morpholino(p-tolyl)methanone 
• 22342-12-7 3-methyl-1-morpholinobutan-1-one 
• 334-19-0 heptanoic acid fluoride 

Downstream Products

• 1002752-21-7 C₁₅H₂₃NO 
• 22342-12-7 3-methyl-1-morpholinobutan-1-one 
• 63833-44-3 morpholino(p-tolyl)methanone 
• 17077-46-2 4-(3-phenyl-propionyl)-morpholine 

Relevant articles and documents

One-Pot Amide Bond Formation from Aldehydes and Amines via a Photoorganocatalytic Activation of Aldehydes

A mild, one-pot, and environmentally friendly synthesis of amides from aldehydes and amines is described. Initially, a photoorganocatalytic reaction of aldehydes with di-isopropyl azodicarboxylate leads to an intermediate carbonyl imide, which can react with a variety of amines to afford the desired amides. The initial visible light-mediated activation of a variety of monosubstituted or disubstituted aldehydes is usually fast, occurring in a few hours. Following the photocatalytic reaction, addition of the primary amine at room temperature or the secondary amine at elevated temperatures leads to the corresponding amide from moderate to excellent yields without epimerization. This methodology was applied in the synthesis of Moclobemide, a drug against depression and social anxiety.

AIBN-initiated metal free amidation of aldehydes using N-chloroamines

An efficient and environmentally benign amidation of aldehydes with N-chloroamines has been developed using AIBN as an initiator. This methodology offers a metal free and base free approach and is endowed with mild reaction conditions, high yields, and good functional group tolerance.

Iron-catalyzed amidation of aldehydes with N-chloroamines

A new direct conversion of aldehydes to amides has been realized, in the presence of iron(III) chloride as a catalyst and using tert-butyl hydroperoxide (TBHP) as an oxidant. Both aliphatic and aromatic aldehydes were successfully reacted with variously mono- and di-substituted N-chloroamines. The methodology has a wide substrate scope, uses cheap and easily available reagents and is characterized by short reaction times. Copyright