184963-74-4Relevant academic research and scientific papers
Synthesis of substituted indole derivatives as a new class of antimalarial agents
Agarwal, Anu,Srivastava, Kumkum,Puri,Chauhan, Prem M.S.
, p. 3133 - 3136 (2005)
A series of substituted indole derivatives were synthesized and evaluated for their in vitro antimalarial activity against P. falciparum. Out of the 24 compounds synthesized six compounds have shown MIC of 1 μg/mL. These compounds are in vitro several fol
Propenone derivatives
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, (2008/06/13)
The present invention relates to propenone derivatives represented by the following formula (I): STR1 wherein R1 represents hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, or YR5 (wherein Y represents S or O; and R5 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or a substituted or unsubstituted cyclic ether residue); R2 and R3 independently represent hydrogen, lower alkyl, or substituted or unsubstituted aralkyl, or alternatively R2 and R3 are combined to form substituted or unsubstituted methylene or ethylene; R4 represents hydrogen, hydroxy, lower alkyl, substituted or unsubstituted aralkyl, lower alkoxy, substituted or unsubstituted aralkyloxy, or halogen; and X represents substituted or unsubstituted indolyl; or pharmaceutically acceptable salts thereof.
PROPENONE DERIVATIVES
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, (2008/06/13)
The present invention relates to propenone derivatives represented by the following formula (I): wherein R1represents hydrogen or lower alkyl; R2and R3independently represent hydrogen, lower alkyl, or substituted or unsubstituted aralkyl, or alternatively R2and R3are combined to form substituted or unsubstituted methylene or ethylene; R4represents hydrogen, hydroxy, lower alkyl, substituted or unsubstituted aralkyl, lower alkoxy, substituted or unsubstituted aralkyloxy, or halogen; and X represents substituted or unsubstituted indolyl, with the proviso that when OR3is on the position 2 or position 6 of the benzene ring, R3is not hydrogen; that when R4is on the position 2 or position 6 of the benzene ring, R4is not hydroxy; and that the combination of OR2, OR3, and R4is not 3,4-dimethoxy or 3,4,5-trimethoxy; or pharmaceutically acceptable salts thereof.
