184969-61-7

Upstream product

• 184969-59-3 β-(3,4-dichlorophenyl)-α-[[[dimethyl(1,1-dimethylethyl)silyl]oxy]-methyl]-4-hydroxy-4-phenyl-1-piperidinebutanol 
• 40807-61-2 4-hydroxy-4-phenylpiperidin 
• 200271-78-9 3-(3,4-dichloro-phenyl)-5-(4-hydroxy-4-phenyl-piperidin-1-yl)-pentane-1,2-diol 
• 184968-70-5 3-(3,4-dichloro-phenyl)-1-(4-hydroxy-4-phenyl-piperidin-1-yl)-pent-4-en-1-one 
• 184968-71-6 1-[3-(3,4-dichloro-phenyl)-pent-4-enyl]-4-phenyl-piperidin-4-ol 
• 184968-61-4 3-(3,4-di-chlorophenyl)-4-pentenoic acid 

Downstream Products

• 184969-63-9 3-(3,4-dichlorophenyl)-1-[[dimethyl(1,1-dimethylethyl)silyl]oxy]-5-(4-hydroxy-4-phenyl-1-piperidinyl)-2-pentanone O-methyloxime 

Relevant academic research and scientific papers

SUBSTITUTED OXIMES AS NEUROKININ ANTAGONISTS

Compounds within the genus represented by structural formula (I) or a pharmaceutically acceptable salt thereof, wherein: T is substituted phenyl or substituted pyridyl; R is H, methyl, ethyl, -CH2CN, -CH2C(O)NH2, -(CH2)3SO3H, -CH2C(O)NHCH3, -CH2C(O)NHOH, -CH2C(O)NHOCH3, -CH2C(O)NHCH2CN, -CH2F, -CH2C(O)NHCH2SO3H, (a), (b), (c), (d) or (e); R is methyl or ethyl; and Z is substituted piperidinyl.

Synthesis and structure-activity relationships of oxime neurokinin antagonists: Discovery of potent arylamides

The structural modification of the benzylic ether region of oxime 1 has resulted in the identification of several novel aryl amides as selective or dual NK1/NK2 antagonists.

Substituted oximes as neurokinin antagonists

Compounds within the genus represented by the structural formula I or a pharmaceutically acceptable salt thereof, wherein: T is substituted phenyl or substituted pyridyl; R4 is methyl or ethyl; and Z is substituted piperidinyl.

SUBSTITUTED OXIMES, HYDRAZONES AND OLEFINS AS NEUROKININ ANTAGONISTS

Compound represented by the structural formula STR1 or a pharmaceutically acceptable salt thereof, wherein: a is 0, 1, 2 or 3;b, d and e are independently 0, 1 or 2;R is H, C 1-6 alkyl,--OH or C 2-C 6 hydroxyalkyl; A is an optionally s