185-72-8

Basic information

• Product Name: 1,6-Dioxaspiro[2.5]octane
• Synonyms: 1,6-Dioxaspiro[2.5]octane;Tetrahydrospiro[oxirane-2,4'-[4H]pyran]
• CAS NO: 185-72-8
• Molecular Formula: C₆H₁₀O₂
• Molecular Weight: 114.14
• Mol File: 185-72-8.mol
• Article Data: 26

Chemical Properties

• Boiling Point: 158.4°Cat760mmHg
• Flash Point: 48.5°C
• Appearance: /
• Density: 1.1g/cm³
• Vapor Pressure: 3.4mmHg at 25°C
• Refractive Index: 1.477
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1,6-Dioxaspiro[2.5]octane(CAS DataBase Reference)
• NIST Chemistry Reference: 1,6-Dioxaspiro[2.5]octane(185-72-8)
• EPA Substance Registry System: 1,6-Dioxaspiro[2.5]octane(185-72-8)

Safety Data

• RIDADR: 1993
• HazardClass: 3
• PackingGroup: Ⅲ
• Hazardous Substances Data: 185-72-8(Hazardous Substances Data)

Usage

General Description

1,6-Dioxaspiro[2.5]octane, also known as Dioxane, is a chemical compound with the molecular formula C4H8O2. It is a colorless liquid with a faint sweet odor and is commonly used as a solvent in various industrial processes, such as in the production of cellulose acetate and in the formulation of lacquers, varnishes, and paint strippers. It is also used as a stabilizer for chlorinated solvents and as a solvent for pharmaceuticals and resins. Dioxane is considered a hazardous chemical because of its potential to contaminate groundwater and its high volatility, which can lead to inhalation exposure and toxic effects on the central nervous system, liver, and kidneys. It is important to handle and dispose of dioxane properly to minimize its impact on human health and the environment.

InChI:InChI=1/C6H10O2/c1-3-7-4-2-6(1)5-8-6/h1-5H2

Upstream product

• 186581-53-3 diazomethane 
• 29943-42-8 Tetrahydro-4H-pyran-4-one 
• 67-56-1 methanol 
• 60-29-7 diethyl ether 
• 5034-06-0 trimethyl sulfoxonium chloride 
• 2181-42-2 trimethylsulphonium iodide 
• 1030268-24-6 trimethylsulphoxonium iodide 
• 1774-47-6 trimethylsulfoxonium iodide 
• 2081-44-9 Tetrahydro-pyran-4-ol 
• 36838-71-8 4-methylene-tetrahydro-pyran 

Downstream Products

• 50675-18-8 3,4,5,6-tetrahydro-2H-pyran-4-carbaldehyde 
• 783303-73-1 4-(aminomethyl)tetrahydro-2H-pyran-4-ol 
• 1210226-44-0 6-methylbenzo[b]thiophene-2-carboxylic acid [1-(2-phenyl-1(R)-{[1-(4-hydroxytetrahydropyran-4-ylmethyl)piperidin-4-ylmethyl]carbamoyl}ethylcarbamoyl)cyclopentyl]amide 
• 1010836-50-6 (4-methoxytetrahydro-2H-pyran-4-yl)methanol 

Relevant articles and documents

Design of iodinated radioligands for SPECT imaging of central human 5-HT4R using a ligand lipophilicity efficiency approach

A series of iodinated ligands for the SPECT imaging of 5-HT4 receptors was designed starting from the previously reported hit MR-26132. We focused on the modulation of the piperidine-containing lateral chain by introducing hydrophilic groups in order to decrease the liphophilicity of the new ligands. All the synthesized compounds were tested for their binding affinities on 5-HT4Rs and based on the Ligand Lipophilicity Efficiency approach, compound 13 was further selected for radioiodination with iodine-125 and imaging experiments. Compound 13 showed its ability to displace the specific signal of the reference compound [125I]SB-207710 but no significant detection of [125I]13 was observed in vivo in SPECT experiments.

AMINO-QUINOLINES AS KINASE INHIBITORS

Disclosed are compounds having the formula:wherein R 1 , R 2 , R 3 and Z are as defined herein, and methods of making and using the same.

ANTI-BACTERIAL COMPOUNDS

A compound of Formula (II): for use in the prevention or treatment of a bacterial infection.