36838-71-8

Basic information

• Product Name: 4-Methylenetetrahydro-2H-pyran
• Synonyms: 4-Methylenetetrahydro-2H-pyran;Tetrahydro-4-methylene-2H-pyran;2H-Pyran, tetrahydro-4-Methylene-;4-Methylenetetrahydropyran;Tetrahydro-4-methylenepyran;4-methylideneoxane
• CAS NO: 36838-71-8
• Molecular Formula: C₆H₁₀O
• Molecular Weight: 98.14
• Mol File: 36838-71-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 122℃
• Flash Point: 15℃
• Appearance: /
• Density: 0.89
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-Methylenetetrahydro-2H-pyran(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methylenetetrahydro-2H-pyran(36838-71-8)
• EPA Substance Registry System: 4-Methylenetetrahydro-2H-pyran(36838-71-8)

Safety Data

• Hazardous Substances Data: 36838-71-8(Hazardous Substances Data)

Usage

Uses

4-Methylideneoxane is used in preparation of griseofulvin derivatives as central nervous system antiinflammatory agents.

Upstream product

• 16302-35-5 4-methyl-3,6-dihydro-2H-pyran 
• 7525-64-6 4-hydroxy-4-methyltetrahydropyran 

Downstream Products

• 129762-37-4 4-Phenylsulfinylmethyl-5,6-dihydro-2H-pyran 
• 132575-96-3 Phenyl-(2-phenyl-1,8-dioxa-2-aza-spiro[4.5]dec-3-yl)-methanone 
• 132576-03-5 2-Phenyl-1,8-dioxa-2-aza-spiro[4.5]decane-3-carboxylic acid phenylamide 
• 185-72-8 1,6-dioxa-spiro[2.5]octane 
• 16302-35-5 4-methyl-3,6-dihydro-2H-pyran 
• 2270-61-3 4-methyl-3,4-dihydro-2H-pyran 
• 4717-96-8 4-methyltetrahydropyran 
• 144-62-7 oxalic acid 
• 77-92-9 citric acid 
• 503-49-1 meglutol 
• 872725-26-3 3-methylenepent-4-en-1-yl 4-methylbenzenesulfonate 
• 14774-37-9 (tetrahydro-2H-pyran-4-yl)methanol 

Relevant articles and documents

EXPERIMENTAL STUDIES OF THE ANOMERIC EFFECT. PART I. 2-SUBSTITUTED TETRAHYDROPYRANS.

Variable temperature (1)H and (13)C n.m.r. studies in CFCl3/CDCl3 of equilibria in 2-substituted- and 2-substituted-4-methyl-tetrahydropyranes have given conformational enthalpy differences and conformational entropy differences for chloro, methoxy, hydroxy and methylamino substituents.For ΔHoa->e, the values obtained, in kcal /mol, were 1.67 (Cl), 0.03 (OCH3), -0.63 (OH) and -1.75 (NHCH3); for ΔSoa->e the values obtained, in cal K-1mol-1 were -1.69 (Cl), -2.52 (OCH3), -2.50 (OH) and -0.60 (NHCH3).The trend in ΔHo values confirms the importance of antiperiplanar n-?* stabilisation as a contributor to the explanation of the anomeric effect, and supports a suggestion that endo- and exo-anomeric effects which occur in the same conformation are competitive.A variable temperature (13)C n.m.r. study of (Me-(13)C)-4-methyl-tetrahydropyran in CD2Cl2 has given a conformational enthalpy difference (ΔHoa->e) of -1.86 kcal/mol and a conformational entropy difference (ΔSoa->e) of -0.07 cal K-1mol-1 for a methyl substituent at the 4-position of a tetrahydropyran.