185030-05-1

Upstream product

• 1460-47-5 2-cyclobutyl-2-hydroxy-2-phenylacetic acid 
• 87120-72-7 1-(tert-butoxycarbonyl)-4-aminopiperidine 
• 530-62-1 1,1'-carbonyldiimidazole 

Downstream Products

• 257603-50-2 N-[1-(3-ethoxycarbonylpropyl)piperidin-4-yl]-2-cyclobutyl-2-hydroxy-2-phenylacetamide 
• 257603-52-4 N-methyl-N-(1-tert-butyloxycarbonylpiperidin-4-yl)-2-cyclobutyl-2-trimethylsiloxy-2-phenylacetamide 
• 257603-51-3 N-(1-tert-butyloxycarbonylpiperidin-4-yl)-2-cyclobutyl-2-trimethylsiloxy-2-phenylacetamide 

Relevant academic research and scientific papers

J-104129, a novel muscarinic M3 receptor antagonist with high selectivity for M3 over M2 receptors

A new class of 4-acetamidopiperidine derivatives has been synthesized and investigated for human muscarinic receptor subtype selectivity. Introduction of a hydrocarbon chain of appropriate length into the piperidine nitrogen of the racemic N-(piperidin-4-

1,4-di-substituted piperidine derivatives

This invention provides novel 1,4-di-substituted piperidine derivatives of the general formula ?I! STR1 and the pharmaceutically acceptable salts thereof, wherein: Ar represents a phenyl group or a five- or six-membered heteroaromatic group having one or two hetero atoms selected from the group consisting of an oxygen atom, a sulfur atom and a nitrogen atom in which one or two optional hydrogen atoms on the ring may be replaced by substituent groups selected from the group consisting of a halogen atom and a lower alkyl group; R1 represents a cycloalkyl group of 3 to 6 carbon atoms or a cycloalkenyl group of 3 to 6 carbon atoms; R2 represents a saturated or unsaturated aliphatic hydrocarbon radical of 5 to 15 carbon atoms; and X represents O or NH. These compounds have selective antagonistic activity against the muscarinic M3 receptors and can hence be used safely with a minimum of side effects.